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Venkatnarayanan, R.
- Simultaneous Estimation of Amoxycillin Trihdrate and Dicloxacillin Sodium in Formulation by UV-Spectroscopy
Authors
1 Department of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore - 641402, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 241-243Abstract
A simple UV- Spectrophotometric method has been developed for simultaneous estimation of Amoxycillin Trihydrate and Dicloxacillin Sodium from Pharmaceutical dosage forms. Methanol: water (1:1) was used as solvent. The method involves the measurement of absorbance at two wavelengths 290 nm (λmax for Amoxycillin) and 274nm (λmax for Dicloxacillin). The linearity lies between 2-10 μg/ml for Amoxycillin and10-50 μg/ml for Dicloxacillin. The accuracy and precision of the methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2. The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Amoxycilin and Dicloxacillin in bulk and combined dosage form.
Keywords
Simultaneous, UV-Spectrophotometric, Amoxycilin, Dicloxacillin.- RP-HPLC Method for Simultaneous Estimation of Tramadol HCl and Paracetamol Bulk Drug and its Combined Dosage Form
Authors
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 552-554Abstract
This work is concerned with application of simple, accurate, precise and highly selective reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Tramadol HCl and Paracetamol in combined dosage form. Chromatographic separation was achieved isocratically at room temperature on phenomenex C18 column (250×4.6 mm) with a mobile phase composed of 5% Tri-fluoroaceticacid in water:Acetonitrile:Methanol in the ratio of 70:20:10% v/v/v at flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 254 nm. The retention time of Tramadol HCl and Paracetamol was found to be 3.890±0.5 min and 1.990±0.5 min respectively. The method was found to be linear in the range of 0.1-10 μg/ml with mean recovery of 98.96% for Tramadol HCl and 99.11% for Paracetamol. The correlation coefficients for all components are close to 1. The developed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed method was successfully applied for simultaneous determination of Tramadol HCl and Paracetamol in routine analysis.Keywords
Tramadol HCl, Paracetamol, RP-HPLC.- Derivatized HPTLC Method for Simultaneous Estimation of Glucosamine, Vitamin C and Vitamin E in Tablets
Authors
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 329-331Abstract
An accurate, precise and derivatized HPTLC method has been developed for the simultaneous estimation of Glucosamine, Vitamin C and Vitamin E in tablet formulation. In this method standard and sample solutions of Glucosamine, Vitamin C and Vitamin E were applied on pre-coated silica gel 60F254 TLC plate, and developed using ethanol:Acetic acid (9:1 v/v), as mobile phase and derivatized using Iodine vapor. The drugs on the plate were scanned at 500 nm. The dynamic linearity range was 20-100 μg/spot for Glucosamine, 2-10 μg/spot for Vitamin C and 0.2-1 μg/spot for Vitamin E. The method was validated for precision, accuracy and reproducibility.Keywords
Simultaneous Estimation, HPTLC, Glucosamine, Vitamin C and Vitamin E.- Computer Aided Docking Studies on Antiviral Drugs for Bird Flu
Authors
1 Dept. of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, (T.N.), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 370-373Abstract
The Protein-Ligand interaction plays a significant role in structural based drug designing. The highly pathogenic influenza A virus subtype H5N1 virus is an emerging avian influenza virus that has been causing global concern as a potential pandemic threat. It is often referred to simply as "bird flu" or "avian influenza". In our research work we have taken influenza A virus H5N1 receptor. The receptor was docked to the commercially available drugs zanamivir and oseltamivir and the energy value obtained are as follows; zanamivir (-231.74) and oseltamivir (-243.74) using the HEX docking software. We tried to improve the binding efficiency and steric compatibility of zanamivir against N5N1 receptor. Several modifications were made to the probable functional groups which were interacting with the receptor molecule. Analogs of this drug molecule were prepared using ACD ChemSketch and docked using HeX docking software. Zanamivir analog 3 and oseltamivir analog 5 were detected with significant energy values and probable lead molecules. The Modified drugs was sketched using Chemsketch were found to be better than the conventional drugs available. Further from this work we can improve the steric compatibility and then ADME properties of the Analogs can be analyzed using Inslico ADME tools available.Keywords
Bird Flu, Chemsketch, Docking, Hex, Rasmol.- Simultaneous RP-HPLC Estimation of Nitazoxanide and Ofloxacin in Tablet Dosage Forms
Authors
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN