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Authors
Affiliations
1 API-R&D, Integrated Product Development, Cipla Ltd, Patalaganga, Mumbai 410220, IN
2 Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G. Nagara- 571448, Mandya, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 4 (2016), Pagination: 153-158
Abstract
In our earlier research, we have reported conventional synthesis and antioxidant activity of thiazolidinone derivatives. During various literature surveys, we found microwave technique is advantageous over conventional synthesis and various derivatives comprising of thiazolidinone group have shown good antimicrobial activity. By considering all these assumption, we have resynthesized our reported products by microwave synthesis and screened them for antimicrobial activity. The microwave assisted synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of all the synthesized compounds were confirmed by IR, 1H NMR, and mass spectral data. The synthesized compounds were evaluated for their antimicrobial activity. Few compounds were found with potent antimicrobial activity.
Keywords
Thiazole, Thiazolidinone, Microwave Synthesis, Schiff’s Bases, Antbacterial Activity, Antifungal Activity.
