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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr.Rafiq Zakaria Campus, Rauza Bagh, P.B. No. 33 Aurangabad (M.S.) 431001, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1712-1716
Abstract
A simple, efficient and green procedure has been developed for the synthesis of novel of 4-(3, 5-diarylsubstituted)-4,5- dihydro-1H-pyrazol-1-yl) benzene sulfonamides using ultrasonic irradiation. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times and milder conditions. A mixture of substituted prop-2-en-1-ones, 4-hydrazinylbenzenesulfonamide hydrochloride and hydrazine hydrate in ethanol and acetic acid was irradiated under ultrasound in an open vessel. The synthesized pyrazolines containing benzenesulphonamide group were evaluated for their anti-inflammatory activity using Carrageenan-induced rat hind paw oedema and have shown promising t anti-inflammatory activity.
Keywords
Green Synthesis, Ultrasound, Pyrazolines, Sulphonamides, Anti-Inflamatory Activity.
