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Authors
Affiliations
1 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, IN
2 Department of Pharmaceutical Sciences, GJUS and T, Hisar, Haryana, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1755-1759
Abstract
An easy access to a series of 1,3,4-oxadiazoles bearing a 1-(naphthalen-2-yl)propan-1-one side chain in the 4-position is described. These compounds were obtained starting from commercially available Naphthalene and aromatic acids. The work involves Friedal craft acylation reaction of hydrocarbons i.e. Naphthalene that result in formation of Aroyl propanoic acid and finally this Aroyl propanoic acid is condensed with different aromatic hydrazides and result in formation of 1,3,4 -oxadiazoles. The resulted compounds were screened for their biological activity.
Keywords
4-(Naphthalen-2-yl)-4-Oxobutanoic Acid, Aromatic Esters, Aromatic Hydrazides, Antiinflammatory Activity and Analgesic Activity.
