Asian Journal of Research in Chemistry

N. Harikrishnan ¹, U. Muralikrishna ¹, P. Satya Vani ¹, M. V. Asha Jyothi ¹, V. Ranjithkumar ¹, V. Haribhaskar ¹

Affiliations
1 Vels University, Dept. of Pharmaceutical Analysis, P.V. Vaithiyalingam Road, Pallavaram, Chennai-600117, IN

Abstract

A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of levocetirizine dihydrochloride in bulk and pharmaceutical dosage form. The UV spectrophotometric method is based on measurement of absorption at maximum wavelength 229 nm. The accuracy of the methods was assessed by recovery studies and was found to be ranging from 97.87-99.70. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 2-10 μg/ml having line equation y=0.026x+0.016 with correlation coefficient of 0.999. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Levocetirizine Dihydrochloride.

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N. Harikrishnan ¹, R. Deepthi ¹, V. Manjusha ¹, P. Satya Vani ¹, M. V. Asha Jyothi ¹, C. Roosewelt ¹

Affiliations
1 Dept. of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, IN

Abstract

A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of loratadine in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 245 nm. The percentage recovery of loratadine is 99% ranged from (99.97±0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-30 μg/ml having line equation y=0.0043x+0.01 with correlation coefficient of 0.99868. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Loratadine.

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N. Harikrishnan ¹, U. Muralikrishna ¹, Basha Shaik ¹, Vishal Bhavsar ¹, V. Manjusha ¹, V. Ranjith Kumar ¹

Affiliations
1 Dept of Pharmaceutical Analysis, Vels University, P.V. Vaithiyalingam Road, Allavaram, Chennai-600117, IN

Abstract

The present research work discussed the development of a UV estimation method for glibenclamide. A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Glibenclamide in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on Measurement of absorption at maximum wavelength 242 nm. The percentage recovery of Glibenclamide ranged from (99.97±0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-30 μg/ml having line equation y=0.0211x-0.0114 with correlation coefficient of 0.9934. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Glibenclamide.

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