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2-amino-4-(4-chlorophenyl)-N-(3-furan-2-ylmethyl carboxamido) thiophenes was synthesized using versatile Gewald reaction .First step is preparation of furfuryl cyanoacetamide which was carried out by condensation of furfuryl amine and ethyl cyano acetate which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4- chlorophenyl)-N-(3-furan-2-yl methyl carboxamido) thiophene (SM-4) later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 4a-4l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.

Keywords

Synthesis, Thiophenes, Schiff Bases, Spectral Analysis, Antimicrobial Activity

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References

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Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives

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Authors

Shivaji Bhattacharjee ¹, J. Saravanan ¹, S. Mohan ¹, Monica Arora ¹

Affiliations
1 Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, IN

Source

Asian Journal of Research in Chemistry, Vol 6, No 3 (2013), Pagination: 244-247

Abstract

The novel 2-amino-3-carbethoxy-4- phenyl thiophene was synthesized by using a acetophenone and ethyl cyano acetate and the parent compound was reacted with chloroacetic acid and glacial acetic acid, the chloro compound was then substituted with different substituted primary and secondary amines to obtain a series of title compounds [SBJa 1-8]. All the new title compounds were characterized by spectral data and were screened for CNS depressant activity. In conclusion, it can be inferred that the electron donating groups on the phenyl ring at R of the title compounds influenced the CNS depressant activity

Keywords

Synthesis, Thiophene, Manich Base, Characterization, CNS Depressant Activity

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References

Isloor AM, Kalluraya B, Pai KS. 2010; Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem.; 45:825–30

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M.A. Gouda, M.A.Berghot, Ghada E,Abd EI.G, A.m. Khalil. 2010; Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrothiophene moiety. Eur J Med Chem.; 1-8

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