Abstract Views :185 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Padmashree Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat, Ahmednagar, MS, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 127-130
Abstract
A series of phthalimide derivatives were synthesized and evaluated for their analgesic and invitro antiinflammatory activity. The target compounds were obtained by condensation of N-hydroxymethylphthalimide with the substituted thiadiazole. The structures of the synthesized derivatives were confirmed by means of IR, 1H-NMR spectral data. The analgesic activity was determined by acetic acid induced writhings in mice and Invitro antiinflammatory activity was evaluated using thermally induced protein denaturation technique. The results revealed the importance of the combination of thiadiazole and phthalimide moieties as a promising analgesic and antiinflammatory candidate.
Keywords
Phthalimide, Analgesic Activity, In-vitro Antiinflammatory Activity, Protein Denaturation Technique.
