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Aruna Devi, M.
- Synthesis and Evaluation of Substituted Imidazolones for Antibacterial and Antioxidant Activities
Authors
1 Institute of Pharmaceutical Tech., Sri Padmavathi Mahila Visvavidyalayam (Women’s University), Tirupati-517 502, IN
2 Trinity College of Pharmaceutical Sciences, Karimnager, A.P., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 257-259Abstract
A series of 4-(substituted benzylidene)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-phenyl -1H-imidazol-5(4H)-ones were synthesized by condensation of 4-benzylidene-2-phenyl-oxazol-5-one with 2-amino-5-phenyl-1,3,4-thiadiazoles in presence of sodium acetate in glacial acetic acid. The intermediate 4-benzylidene-2-phenyl-oxazol-5-ones were prepared by condensing benzaldehydes with benzoyl glycine in presence of acetic anhydride and sodium acetate. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR. All the compounds (10-18) were screened for antibacterial and antioxidant activities. Among all, the compounds 12, 16 exhibited highest antibacterial activity against all the four strains. Compound 12 exhibited highest nitric oxide scavenging activity and most of these compounds showed significant DPPH scavenging activity.
Keywords
Imidazolone, Antibacterial Activity, Antioxidant Activity.- Synthesis and Pharmacological Screening of Some New Benzimidazole Derivatives
Authors
1 Tallapadmavathi College of Pharmacy, Urus, Kareemabad, Warangal, A.P, IN
2 Trinity College of Pharmaceutical Sciences, Peddapalli, Karimnagar, A.P, IN
3 Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, A.P, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 147-150Abstract
Seven different 2-[(1H-benzimidazol-2yl methyl) sulfanyl)] –N4-(phenylmethylidene) acetohydrazides were synthesized from 2-[(1H- benzimidazol-2-yl methyl) sulfanyl] acetohydrazide on reaction with different aromatic aldehydes in methanol. Each of these compounds were purified and characterized by their spectral data. All the compounds were assayed for their anti-inflammatory activity by carrageenan induced rat hind paw edema method. Some of these compounds showed moderate to considerable anti-inflammatory activity.