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Authors
Affiliations
1 P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Ahmednagar, 414 111, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1722-1725
Abstract
In these study, a series of N2-substituted Dihydrophthalazine-1,4-dione Derivatives (2a-2o) were synthesized from phthalic anhydride and aromatic acid hydrazides (1a-1o) using microwave irradiation. The synthesized compounds were confirmed by IR and1H NMR studies. Synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock (MES) method. Neurologic deficit was evaluated by the rotarod test. All the compounds exhibited significant anticonvulsant activity. Compounds 2a, 2b, 2i and 2o were most active of the series against MESinduced seizures.
Keywords
Microwave Irradiation, Phthalazine, Anticonvulsant Activity, Neurotoxicity Study.
