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Authors
Affiliations
1 Fisher BioPharma Services (India) Pvt. Ltd, "PHARMEZ" SEZ, Plot No 22, Matoda, National Highway 8A, Ahmedabad-382213, Gujarat, IN
2 K.L.E.S’s College of Pharmacy, JNMC Campus, Belgaum-590010, Karnataka, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 685-687
Abstract
Various derivatives of 4-thaizolidinones were synthesized by reacting Schiff bases with thioglycollic acid. These alcoholic groups were further oxidized to get the carboxylic acid derivatives. The compounds were purified using flash chromatography and were characterized by physical, chemical and elemental analysis. The compounds were screened for calcium antagonistic activity on albino rats by using Biopack data acquisition system. Some compounds showed comparable activity with standard drug Diltiazem.
Keywords
4-Thiazolidinones, Calcium Antagonist, Calcium Channel Blockers, Schiff Bases.
