Asian Journal of Research in Chemistry

D. Rebecca Shiffali ¹, K. Ramakrishna ¹

Affiliations
1 Dept. of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Hyderabad-90, IN

Abstract

An inexpensive, simple, precise and rapid method for the determination of pioglitazone hydrochloride in bulk and in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, accuracy and recovery test. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. Besides this, TLC Profile of pioglitazone hydrochloride formulation was also recorded, which showed the presence of pioglitazone hydrochloride, when compared with standard with Rf value 0.62 in a solvent system.

Keywords

Non-Aqueous Titration, Pioglitazone Hydrochloride, Perchloric Acid, TLC.

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S. V. V. Dhanu Radha ¹, K. M. Ch. Apparao ¹, K. Ramakrishna ¹

Affiliations
1 Department of Chemistry-Gitam Institute of Technology, Gitam Institute of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh, IN

Abstract

Two simple, economical, precise and reproducible visible spectrophotmetric methods have been developed for the estimation of aripiprazole in bulk formulation. The developed methods are based on the formation of charge transfer coloured complex of aripiprazole with N-Bromo succinimide and complex with chloramine-T using double distilled water. The complex with N-Bromo succinimide shows absorbance maxima at 520.0 nm and linearity in the concentration range of 1-20 μg/ml. The extracted complex with chloramine-T shows absorbance maxima at 540.0 nm and the linearity in the concentration range of 0.2-0.8 μg/ml. Results of analysis for both the methods were validated statistically and by recovery studies.

Keywords

Aripiprazole, UV-Visible Spectrophotometry, Ultra Sonicator, Electronic Balance, Millipore Double Distilled Water, N-Bromosuccinimide, Chloramine-T, Gallocyanine.

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