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Rajasekhar, K. K.
- Insilico Prodrug Designing of Some Matrix Metallo Proteinase Inhibitors Derived from Tanomastat
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Authors
Affiliations
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, AP, IN
2 CMR College of Pharmacy, Hyderabad, AP, IN
3 Dept. of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, AP, IN
1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, AP, IN
2 CMR College of Pharmacy, Hyderabad, AP, IN
3 Dept. of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, AP, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 411-415Abstract
The present work describes the insilico prodrug designing of Tanomastat, a matrix metalloproteinase inhibitor. Tanomastat was selected as a lead and a series of prodrug-like molecules derived from it were generated. The pharmacokinetic and toxicity profile of these prodrug-like molecules was obtained by using ADME and TOX boxes web version of pharma Algorithms and ACD labs Chem Sketch software version 12.0. All prodrug-like molecules were predicted to be lipophilic, less toxic with an enhanced protein binding and better therapeutic efficacy. In conclusion, ADME and Toxicity properties of these molecules suggest advantages over Tanomastat.Keywords
Insilico Prodrug Designing, Tanomastat, Matrix Metallo Proteinase Inhibitor (MMPI), Pharmacokinetic and Toxicity Profile.- RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations
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Authors
Y. Rajendraprasad
1,
K. K. Rajasekhar
2,
V. Shankarananth
2,
S. Bharath Kumar
2,
G. Dileep Kumar
2,
T. Sreelekha
2
Affiliations
1 Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, IN
2 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, IN
1 Department of Pharmaceutical Chemistry, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, A.P, IN
2 Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, A.P, IN