Asian Journal of Research in Chemistry

Hemant Badwaik ¹, S. Venkataraman ², Deepa Thakur ¹, Minu Vinod ¹, J. Raamamurthy ¹, Kiran Deshmukh ²

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
2 K.M. College of Pharmacy, Madurai (T.N), IN

Abstract

Acetanilide was cyclized via Vilsmeier-Haack reagent to give 2- chloro -3- formyl quinoline. The aldehydic group was protected to prevent the preferential attack of nitrogen nucleophiles. The protection of aldehydic group in the present system was achieved with ethylene glycol to afford dioxolan derivative. Dioxolan derivative treated with nitro substituted phenyl hydrazine in alcoholic solution followed by deprotection of aldehydic group afforded the 2-(2-(2- nitrophenyl) hydrazinyl) quinoline-3-carbaldehyde and 2-(2-(2, 4-dinitrophenyl) hydrazinyl) quinoline-3- carbaldehyde. The synthesized derivatives were screened for antimicrobial activity.

Keywords

Vilsmeier–Haack Reagent, Dioxolan, 2-(2-(2, 4-Dinitrophenyl) Hydrazinyl) Quinoline-3- Carbaldehyde, Antimicrobial Agent.

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