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Narendra Sharath Chandra, J. N.
- Synthesis of Substituted Thienopyrimidines and Their Evaluation as Antibacterial
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II main, 100 Ft Ring Road, BSK II Stage, Bangalore- 560085, IN
2 Department of Chemistry, Texas State University, San Marcos, US
1 Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II main, 100 Ft Ring Road, BSK II Stage, Bangalore- 560085, IN
2 Department of Chemistry, Texas State University, San Marcos, US
Source
Asian Journal of Research in Chemistry, Vol 6, No 2 (2013), Pagination: 177-181Abstract
We have synthesized various substituted thieno(2,3-d)pyrimidines, first by synthesizing ethyl 2-aminothiophene-3- carboxylate (3), by treatment of diethane with ethyl cynoacetate in presence of triethylamine, acetic acid and DMF. Further, the intermediate Ethyl 2-(ethoxycarbonyl)thiophene-3-carboxylate (5) was prepared by compound (3) refluxed with ethyl chloroformate. The key intermediate 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1H, 3H)-dione (7) was prepared by cyclisation of compound (5) with 3-chloro-4-fluoro aniline. The nucleophilic substitution of compound 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1 H, 3 H)-dione (7) with various aromatic amines(8a-m), aminophenol(8n) gives substituted thienopyrimidines(8a-n). The synthesized new compounds were characterized by MP, TLC, IR and NMR spectra.Keywords
Thienopyrimidine
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