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Amachree, I.
- Diabinese and Nicotinic Acid Combination Reduced Cardiovascular Indices in Experimental Diabetes
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Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Authors
Affiliations
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
2 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, NG
1 Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, NG
2 Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, NG
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 785-790Abstract
Background:Cardiovascular diseases with high levels of creatine kinase have been reported in diabetics as major killer, globally. Can single effect of diabinese(DB)- antidiabetic drug and combined effects of DB and nicotinic acid (NA)-a vitamin and an antilipidemic drug be used to manage diabetes and this associated cardiovascular disease?Method:Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10 mg DB, 10 mg DB/150 mg NA, 10 mgDB/200 mg NA, 10 mg DB/250 mg NA, and 5 ml of Distil water respectively.
Result:Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion:Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.