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Gharge, Deepali
- Validated Spectroscopic Method for Estimation of Aceclofenac from Tablet Formulation
Abstract Views :165 |
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Authors
Deepali Gharge
1,
Pallavi Salve
1,
Chandrakant Raut
1,
Chottaram Seervi
1,
Kundan Pawar
1,
Pandurang Dhabale
1
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 87-89Abstract
Aceclofenac is a non steroidal anti-inflammatory drug with good analgesic and anti-rheumatic properties. Various methods for analysis of the same are available but are time consuming and expensive. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of aceclofenac from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. Absorption maxima of aceclofenac in methanol diluted with glass double distilled water was found to be at 273 nm. Beer’s law was obeyed in concentration range 2-20 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.Keywords
Aceclofenac, UV-Spectrophotometry, Recovery, Accuracy.- Microwave Chemistry:A Review
Abstract Views :171 |
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Authors
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 9-16Abstract
Microwave chemistry involves the use of microwave radiation to conduct chemical reactions, and essentially pertains to chemical analysis and chemical synthesis. The fundamental mechanism of microwave heating involves agitation of polar molecules or ions that oscillate under the effect of an oscillating electric or magnetic field. In the presence of an oscillating field, particles try to orient themselves or be in phase with the field. Only materials that absorb microwave radiation are relevant to microwave chemistry. These materials can be categorized according to the three main mechanisms of heating, namely:Dipolar polarization, Conduction mechanism, Interfacial polarization. Microwave chemistry apparatus are classified:Single-mode apparatus and Multi-mode apparatus.Keywords
Microwave Chemistry, Microwave Synthesis, Mechanism, Advantages.- Simultaneous UV Spectrophotometric Method for Estimation of Amlodipine Besylate and Lisinopril in Tablet Dosage Form
Abstract Views :159 |
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Authors
Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 201-204Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Amlodipine Besylate and Lisinopril in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 239 nm and 207 nm as two analytical wavelengths for both drugs in Triple distilled water. The second method is Q value analysis based on measurement of absorptivity at 212.5 nm (as an iso-absorptive point) and 239 nm. Amlodipine Besylate and Lisinopril at their respective λmax 239 nm and 207 nm and at isoabsorptive point 212.5 nm shows linearity in a concentration range of 5-30 μg/mL. Recovery studies range from 101.49% for Amlodipine Besylate and 99.27% for Lisinopril in case of simultaneous equation method and 100.76% for Amlodipine Besylate and 99.73% for Lisinopril in case of Q-analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.Keywords
Amlodipine Besylate, Lisinopril λmax, Simultaneous Equation Method, Q Analysis.- Development and Validation of UV Spectrophotometric Method of Ambroxol Hydrochloride in Bulk and Pharmaceutical Formulation
Abstract Views :154 |
PDF Views:0
Authors
Chhotaram Seervi
1,
Kundan Pawar
1,
P. N. Dhabale
1,
I. D. Gonjari
1,
Chandrakant Raut
1,
Deepali Gharge
1
Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 547-549Abstract
Two simple, precise and economical UV methods have been developed for the estimation of Ambroxol Hydrochloride in bulk and pharmaceutical formulations. Ambroxol Hydrochloride has the absorbance maxima at 246.5 nm (Method A), and in the first order derivative spectra showed sharp peak at 240 nm (Method B). Linearity for detector response was observed in the concentration range of 10-50 μg/ml for all two methods. The proposed methods were successfully applied for the estimation of Ambroxol Hydrochloride in commercial pharmaceutical preparation by using simple solvent Distilled water. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, Limit of Detection and Limit of Quantification and specificity were found to be satisfactory.Keywords
Ambroxol Hydrochloride, UV Spectrophotometry, Absorbance Maxima, Derivative Spectroscopy.- Simple Validated Spectroscopic Method for Estimation of Amlodipine Besylate from Tablet Formulation
Abstract Views :151 |
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Authors
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN