Asian Journal of Research in Chemistry

L. T. Thote ¹, A. R. Umarkar ¹, D. R. Chaple ¹

Affiliations
1 J. L. Chaturvedi College of Pharmacy, Electronic Zone Building MIDC, Hingna Road, Nagpur, Maharashtra, Pin 400016, IN

Abstract

A new, simple, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Atorvastatin and Telmisartan For this, simultaneous equation method is used. The method involved measurement of absorbance at two wavelengths, 246.20 nm and 290 nm, _ max of Atorvastatin and Telmisartan respectively. Beer's law obeyed in concentration range of 5-30 μg/ mL and 5-30 μg/ mL for Atorvastatin and Telmisartan respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no

organic solvent extraction. This paper describes the development and validation of UV spectroscopic method for Simultaneous estimation of Atorvastatin and Telmisartan in combined solid dosage form.

Keywords

Atorvastatin, Telmisartan, Simultaneous Equation Method.

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N. A. Pendharkar ¹, D. R. Chaple ¹

Affiliations
1 J. L. Chaturvedi College of Pharmacy, MIDC, Hingna Road, Electronic Zone Building, Nagpur-440016, IN

Abstract

A simple, precise and accurate spectrophotometric method has been developed for simultaneous estimation of ambroxol hydrochloride and azithromycin in combined dosage form using multicomponrent mode of analysis. It involves the measurements of absorbance at five selected wavelengths 215 nm, 258 nm, 260 nm, 300 nm and 307 nm using methanol and sodium hydroxide (0.2 N) as a solvent. Linearity was observed in the range of 10-80 μg/mL for mixture. The recovery studies confirmed the accuracy of the proposed method. The results were validated as per ICH guidelines.

Keywords

Azithromycin, Ambroxol Hydrochloride, Multicomponent Mode.

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K. P. Bhusari ¹, D. R. Chaple ¹

Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Higana Road, Nagpur-441110, Maharashtra, IN

Abstract

Two simple, sensitive, accurate and economical spectrophotometric methods were developed for the estimation of ofloxacin and ornidazole simultaneously in tablet dosage form. First method is based on the simultaneous equations and second method is based on Q-analysis (absorbance ratio method). Ofloxacin and ornidazole shows absorbance maxima at 294 nm and 317 nm in N/2 acetic acid, respectively. The linearity was obtained in the concentration range of 2-10 μg/ml for ofloxacin and 2-30 μg/ml for ornidazole. In the first method, the concentrations of the drugs were determined by using simultaneous equations; and in the second method, the concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λmax of the one drug. The results of analysis have been validated statistically and by recovery studies.

Keywords

Ofloxacin, Ornidazole, Spectrophotometry, Validation.

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