Asian Journal of Research in Chemistry

Chetan M. Bhalgat ¹, Prasad P. Talekar ¹, C. Puttaraj ², B. Ramesh ²

Affiliations
1 API-R&D, Integrated Product Development, Cipla Ltd, Patalaganga, Mumbai 410220, IN
2 Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G. Nagara- 571448, Mandya, IN

Abstract

In our earlier research, we have reported conventional synthesis and antioxidant activity of thiazolidinone derivatives. During various literature surveys, we found microwave technique is advantageous over conventional synthesis and various derivatives comprising of thiazolidinone group have shown good antimicrobial activity. By considering all these assumption, we have resynthesized our reported products by microwave synthesis and screened them for antimicrobial activity. The microwave assisted synthesis was found advantageous over conventional by reducing reaction time, increasing yield and lesser usage of solvent. Structures of all the synthesized compounds were confirmed by IR, ¹H NMR, and mass spectral data. The synthesized compounds were evaluated for their antimicrobial activity. Few compounds were found with potent antimicrobial activity.

Keywords

Thiazole, Thiazolidinone, Microwave Synthesis, Schiff’s Bases, Antbacterial Activity, Antifungal Activity.

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Sachin Patil ¹, B. Ramesh ¹, A. R. Hareesh ¹, Kiran Patil ², Ashok Dhokane ²

Affiliations
1 Shri Adichunchunagiri College of Pharmacy, B. G. Nagara, Tal Nagmangala, Dist Mandya, Karnataka, IN
2 Government College of Pharmacy, Vidyanagar, Karad-415124, Dist Satara, Maharashtra, IN

Abstract

Simple, precise, sensitive and reproducible quantitative reverse phase HPLC method has been developed for estimation of Sitagliptin phosphate in pharmaceutical dosage form. The method was carried out on a Phenomenex RP-18 (2) Column (250×4.6 mm i.d; particle size 5 μm) column with a mobile phase consisting of (60:40 v/v Acetonitrile:water) at a flow rate of 1.0 ml/min. The eluents were monitored at 272 nm. The retention time of Sitagliptin phosphate was found out to be 5.062. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantification. The proposed method can be used for the estimation of this drug in pharmaceutical dosage forms.

Keywords

Sitagliptin Phosphate, Validation, Estimation.

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B. Ramesh ¹, B. Someswara Rao ¹, S. V. Kulkarni ¹

Affiliations
1 Dept. of Pharmaceutical Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, IN

Abstract

Some new chalcones have been synthesized by the condensation of 2-acetyl thiophene with various aromatic aldehydes in 40% alkali. The synthesized compounds were identified by spectral data and screened for anti-inflammatory activity. Some of these compounds showed moderate to considerable anti-inflammatory activity.

Keywords

Chalcone, Synthesis, Anti-Inflammatory Activity.

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B. Ramesh ¹, R. N. Umashankar ¹, S. Babitha ¹

Affiliations
1 Dept. of Pharma. Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, IN

Abstract

Some new pyrimidine derivatives were synthesized by reacting chalcones of 2-acetyl thiophene with guanidine hydrochloride in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for anti-inflammatory activity. Some of these compounds showed moderate to considerable anti-inflammatory activity.

Keywords

Synthesis, Pyrimidines, Anti-Inflammatory Activity.

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