Asian Journal of Research in Chemistry

Freddy H. Havaldar ¹, Azadkumar S. Sharma ¹

Affiliations
1 Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001

Abstract

A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino- 4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.

Keywords

Synthesis, Oxadiazole, Antibacterial And Antifungal Activity

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Freddy H. Havaldar ¹, Azadkumar S. Sharma ¹, Peter Roni F. Pinto ¹

Affiliations
1 Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001, IN

Abstract

The acid hydrazides (I and IV) were condensed with indole-2,3-dione in ethanol to yield hydrazono-indolin-2-ones (II and V) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-hydrazono-indolin-2-ones (IIIa-e and VIa-e). The structures of the newly synthesized compounds have been confirmed by IR, ¹H NMR and Mass spectra. These compounds have shown promising biological activity.

Keywords

Synthesis, Mannich Bases, Biological Activity and Spectral Data.

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