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Karadi, Arvind B.
- Spectrophotometric Determination of Cefditoren Pivoxil by Diazotization Coupling Reaction in Solid Dosage Forms
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka-585105, IN
1 Department of Pharmaceutical Analysis, HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka-585105, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 9 (2011), Pagination: 1478-1481Abstract
Three simple, sensitive spectrophotometric methods (Method A, B and C) are developed based on the diazotization of Cefditoren Pivoxil with nitrous acid (NaNo2/HCl) at cold temperature followed by its coupling in-situ with β napthol (Method A) to yield deep purple coloured chromogen, diphenyl amine (Method B) to yield pink coloured chromogen, BMR (Method C) to yield purple coloured chromogen, exhibiting absorption maxima at 542, 506 and 539nm, respectively. Beer's law was obeyed in the concentration ranges of 20-60, 10-50 and 5-30μg/ml respectively. The coloured chromogen was stable for 3-5hrs. These methods were extended to pharmaceutical formulations and there was no interference from any common excepients which are usually present in tablet dosage formulations. The results of analysis have been validated statistically and by recovery studies.Keywords
Cefditoren Pivoxil, Spectrophotometry, β Napthol, Diphenyl Amine, BMR.- Spectrophotometric Determination of Mesalamine by Diazotization Coupling Reaction in Solid Dosage Forms
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, HKES’s College of pharmacy, Sedam Road, Gulbarga, Karnataka-585105, IN
1 Department of Pharmaceutical Analysis, HKES’s College of pharmacy, Sedam Road, Gulbarga, Karnataka-585105, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 968-970Abstract
Two simple, sensitive spectrophotometric methods (Method A and B) are developed based on the diazotization of Mesalamine with nitrous acid (NaNo2/ HCl) at cold temperature followed by its coupling in-situ with Chromotropic acid (Method A) to yield cherry red coloured chromogen, phloroglucinol (Method B) to yield yellow coloured chromogen, exhibiting absorption maxima at 433nm and 421nm , respectively. Beer's law was obeyed in the concentration ranges of 5-25 and 8-40g/ml respectively. The coloured chromogen was stable for 4hrs. These methods were extended to pharmaceutical formulations and there was no interference from any common excepients which are usually present in tablet dosage formulations. The results of analysis have been validated statistically and by recovery studies.Keywords
Mesalamine, Spectrophotometry, Chromotropic Acid, Phloroglucinol.- Determination of Diacerein by a Simple Isocratic RP-HPLC Method
Abstract Views :182 |
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Authors
Arvind B. Karadi
1,
M. Kalpana Jyothi
1,
Ch. Shiva Kumar
1,
S. Appala Raju
1,
Shobha Manjunath
1,
Ashok L. Ganure
2
Affiliations
1 Matoshree Tarabai Rampure Institute of Pharmaceutical Sciences, Gulbarga-585105 (K.S.), IN
2 K.J. College of Pharmacy, Vadasma (North Gujarat), IN
1 Matoshree Tarabai Rampure Institute of Pharmaceutical Sciences, Gulbarga-585105 (K.S.), IN
2 K.J. College of Pharmacy, Vadasma (North Gujarat), IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 581-584Abstract
A Simple and precise reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and validated for the quantitative determination of Diacerein in bulk and its pharmaceutical formulations. Chromatographic separation was performed by using column XDB C8 (4.6×150 mm, 5 μm) with a mobile phase comprising of a mixture of phosphate buffer and Acetonitrile (50:50,v/v) and pH adjusted to 3 with orthophosphoric acid, at a flow rate of 0.8 ml/min with detection at 254 nm. Separation was completed in less than 10 min. As per ICH guidelines the method was validated for linearity, accuracy, precision, limit of quantitation, limit of detection, ruggedness and robustness. Linearity of Diacerein was found to be in the range of 10-100 μg/ml and correlation coefficient was found to be 0.999. The retention time of Diacerein was 3.3 min; the separation was performed at an ambient temperature. The limit of Detection and limit of quantitation for Diacerein was found to be 3.6 and 9.95 (S/N ratio). There was no significant difference in the intraday and inter day analysis of Diacerein determined for five different concentrations using this method. The RSD value 0.3% indicates a high precision of the analytical method. The proposed method was simple, sensitive, precise, accurate and useful for routine quality control analysis.Keywords
Diacerein, RP-HPLC.- New Spectrophotometric Methods for the Estimation of Cefditoren Pivoxil
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Authors
Affiliations
1 HKE’s College of Pharmacy, Gulbarga-585105 (KS), IN
1 HKE’s College of Pharmacy, Gulbarga-585105 (KS), IN