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Umarkar, A. R.
- Development of UV Spectrophotometric Methods for Simultaneous Estimation of Atorvastatin and Telmisartan in Combined Dosage Form Using Simultaneous Equation Method
Authors
1 J. L. Chaturvedi College of Pharmacy, Electronic Zone Building MIDC, Hingna Road, Nagpur, Maharashtra, Pin 400016, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1777-1779Abstract
A new, simple, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Atorvastatin and Telmisartan For this, simultaneous equation method is used. The method involved measurement of absorbance at two wavelengths, 246.20 nm and 290 nm, _ max of Atorvastatin and Telmisartan respectively. Beer's law obeyed in concentration range of 5-30 μg/ mL and 5-30 μg/ mL for Atorvastatin and Telmisartan respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no
organic solvent extraction. This paper describes the development and validation of UV spectroscopic method for Simultaneous estimation of Atorvastatin and Telmisartan in combined solid dosage form.
Keywords
Atorvastatin, Telmisartan, Simultaneous Equation Method.
- Simultaneous Estimation of Cefixime Trihydrate and Ofloxacin by UV Spectrophotometer Using Multicomponent Method
Authors
1 Shri Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner (Jalgaon) M.S. Pin: 424206, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 708-710Abstract
A new simple, specific, precise and accurate multicomponent method has been developed for simultaneous estimation of Cefixime (CEF) and Ofloxacin (OFL) in capsule formulation. The detection of the constituents was done using UV detector at 262,269,278,281,286 for CEF and OFL. Recovery, study values of CEF and OFL is 100.04±0.34 and 99.98±0.27 respectively, relative standard deviation of less than 2% for the assay and linearity coefficient of 0.9998 that the method is precise, accurate and linear in the concentration given and demonstrated the method developed is rugged. Liner response obtained for CEF was in the concentration range 5-20 μg/mL and OFL in the range 2-10 μg/mL.Keywords
Cefixime Trihydrate, Ofloxacin, Absorption Ratio, Multicomponent.- Simultaneous Spectrophotometric Estimation of Thiocolchicoside and Diclofenac Potassium in Combined Capsule Dosage Form
Authors
1 Shri Sureshdada Jain Institute of Pharmaceutical Education and Research, Department of Pharmaceutical Chemistry, Jamner, (Jalgaon) M.S. 424206, IN
2 J.L.Chaturvedi College of Pharmacy, Electronic Zone Building MIDC Hingna Road Nagpur, Nagpur 440016 M.S., IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 370-372Abstract
Two simple, rapid, accurate and economical analytical methods have been developed for the simultaneous estimation of Thiocolchicoside and Diclofenac potassium in combined capsule dosage form. First method is based on the determination of Q-value and Second method is based on simultaneous equation method. Thiocolchicoside has absorbance maxima at 259 nm and Diclofenac potassium has absorbance maxima at 271 nm in distilled water and phosphate. The absorption ratio (Q-value) was determined at 264 nm (Iso-absorptivity point) and 259 nm (_max of Thiocolchicoside Both the drugs obey Beer’s law in the concentration ranges employed for these methods. Both the methods were found to be simple, rapid, and accurate and can be adopted in routine analysis of drugs in formulations. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.