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- Stability Indicating Absorption Ratio Method for Determination of Domperidone and Esomeprazole Magnesium in Capsule Dosage Form Using UV-Spectrophotometer
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly (U.P.)
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University, Bareilly (U.P.)
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 735-739Abstract
A new stability indicating absorption ratio method was developed and validated for the determination of Esomeprazole magnesium (ESO) and Domperidone (DOM) in capsule dosage form. The maximum wavelength (λ max) was found to be 299nm for ESO and 287nm for DOM. The iso-absorptive point of both the drug was found to be 290 nm. The linearity range was found to be 1-6 μg ml<SUP>-1</SUP>(r<SUP>2</SUP>= 0.998) and 5-30 µg ml<SUP>-1</SUP>(r<SUP>2</SUP>= 0.999) for ESO and DOM respectively. The value of limit of detection and limit of quantification was 0.116µgml<SUP>-1</SUP> and 0.386µgml-1 for ESO and 0.657µgml<SUP>-1</SUP> and 2.18µgml<SUP>-1</SUP> for DOM respectively. Forced degradations were carried out under acid, base, thermal, photolytic and oxidative stress conditions. The method was satisfactorily validated as per ICH guideline. The result of study showed that the proposed spectrophotometric method is useful for the routine determination of ESO and DOM in its combined pharmaceutical dosage form.Keywords
Esomeprazole Magnesium, Domperidone, Spectrophotometric Method, Forced Degradation Studies, Absorption Ratio MethodReferences
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- Solanki S, Captain D, Patel BV. Simultaneous determination of domperidone and esomeprazole magnesium in pharmaceutical capsule formulation by derivative spectrophotometric method. International Journal of Chemical and Technological Research. 3(4); 2011:1747-1750
- Singh S, Dubey N, Jain DK. Simultaneous estimation of atorvastatin, clopidogrel and aspirin in capsule dosage form using UV-Spectroscopy. Asian Journal of Research in Chemistry. 3(4); 2010: 885-887.
- Singh S, Yadav AK, Gautam H. Simultaneous estimation of valsartan and hydrochlorothiazide in solid dosage form using UV- Spectroscopy. Bulletin of Pharmaceutical Research. 1(3); 2011: 10-12.
- Patel K, Singh S, Sahu p, Trivedi P. Development and validation of stability indicating assay method for naratriptan by ultra performance liquid chromatography. Scholar Research Library. 3(6): 102-107.
- Singh S, Dubey N, Jain DK. Simultaneous estimation of cefpodoxime proxetil and clavulate potassium combined dosage form using UV-Spectroscopy and reverse phase liquid chromatography. International Journal of Pharmaceutical and Biomedical Science. 5(1); 2011: 57-60.
- Singh S, Yadav AK, Gautam H. First Order Derivative Spectrophotometric Determination of Telmisartan in Pharmaceutical Formulation. Bulletin of Pharmaceutical Research. 2(2); 2012: 83-86.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Simultaneous estimation of S(-) Amlodipine Besylate Hemipentahydrate and Losartan Potassium in Combined Dosage Form by Using UVSpectroscopy. Scholar Research Library. 4(3); 2002: 897-905.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Stability Indicating HPTLC Method for Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets. International Journal of Pharmaceutical and Pharma. Science. 4(4); 2012: 468-471.
- Singh S, Inamullah, Rai J, Choudhary N, Sharma S. Stability Indicating UV-VIZ specrophotometeric method for estimation of atorvastatin calcium and fenofibrate in tablet dosage form. Bulletin of Pharmaceutical Research. 2(3); 2012: 159-166.
- Estimation of Lansoprazole and Naproxen by Absorption Ratio Method in Tablet Dosage Form
Abstract Views :537 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
1 Department of Pharmaceutical Chemistry, Invertis Institute of Pharmacy, Invertis University. Bareilly (U.P.)
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 745-748Abstract
An accurate, specific and precise new Absorption Ratio method was developed for the simultaneous determination of Lansoprazole and Naproxen. The method involved Q-absorption analysis based on the measurement of absorbance at two wavelengths, i. e max of Lansoprazole (284nm) and for Naproxen was (271nm) and Iso-absorptive point of both drugs (275nm). The linearity was found to be 10-35µg/ml (r2 =0·999) for NAP and 5-30µg/ml (r 2 =0·998) for LAN. Validation was performed as ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The limit of quantification of NAP was found to be 0·15µg/ml and for LAN was 1·7µg/ml. The limit of detection of NAP was found to be 0·04µg/ml and for LAN was 0·5µg/ml. The indicating proposed spectrophotometric method was accurate and precise for estimation of NAP and LAN in tablet dosage formKeywords
Lansoprazole, Naproxen, Iso-absorptive PointReferences
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- Singh S, Yadav AK, Gautam H. First order derivative spectrophotometeric determination of Telmisartan in pharmaceutical formulation. Bullatine of Pharmaceutical Research.2(2); 2012: 83-86.
- Moustafa AAM. Spectrophotometric methods for the determination of lansoprazole and pantoprazole sodium sesquihydrate. Journal of Pharmaceutical and Biomedical Analysis. 22; 2000: 45-58.
- Wahbi AAM, Razak AO, Mahgoub H, Azza A, Moneeb MS. Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis. 30; 2002: 1133-1142.
- Singh S, Inamullah, Rai J, Choudhary N, Sharma S. Stability Indicating UV-VIZ specrophotometeric method for estimation of atorvastatin calcium and fenofibrate in tablet dosage form. Bullatine of Pharmaceutical Research. 2(3); 2012: 159-166.
- Mehta P, Sharma SC, Nikam D, Ranawat MS. Development and Validation of Related Substances Method by HPLC for Analysis of Naproxen in Naproxen Tablet Formulations. International Journal of Pharmaceutical Science and Drug Research. 4(1); 2012: 63-69.
- Reddy SP, Sait S, Vasudevmurthy G, Vishwanath B, Prasad V, Reddy J. Stability indicating simultaneous estimation of assay method for naproxen and esomeprazole in pharmaceutical formulations by RP-HPLC. Der Pharmacia and Chemicals. 3(6); 2011: 553-564.
- Pawar MS, Patil SB, Patil YR. Validated HPTLC Method for Simultaneous Quantitation of Domperidone Maleate and Naproxen Sodium in Bulk Drug and Formulation. Eurasian Journal of Analytical Chemistry. 5(3); 2010: 284-292.
- Md. Mondal S, Md. Haque A, Md.Islam S, Islam A. Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Domperidone and Naproxen in Tablet Dosage Form. Journal of Applied Pharmaceutical Science. 1(7); 2011: 145-148.
- Patel B, Dedanta Z, Dedanta R, Ramolla C, Sagar GV, Mehta RS. Simultaneous Estimation of Lansoprazole and Domperidone in Combined Dosage Form by RP-HPLC. Asian Journal of Research Chemistry. 2(2); 2009: 210-212.
- Janardhanan VS, Manavalan R, Valliappan K. Stabilityindicating HPLC method for the simultaneous determination of pantoprazole, rabeprazole, lansoprazole and domperidone from their combination dosage forms. International Journal of Drug Development and Research. 3(4); 2011: 323-335.
- Reddy BP, Jayaprakash M, Sivaji K, Kumar GTJ, Reddy ECS, Reddy BR. Determination of Pantoprazole Sodium and Lansoprazole In Individual Dosage Form Tablets By RP-HPLC Using Single Mobile Phase. International Journal of Applied Biomedical and Pharmaceutical Technology. 1(2); 2010: 683- 688.
- Kumar SM, Kumar DS, Rajkumar T, Kumar EU, Geetha AS, Diwedi D. Development and validation of RP-HPLC method for the estimation of Lansoprazole in tablet dosage form. Journal of Chemicals and Pharmaceutical Research. 2(6); 2010: 291-295.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Stability Indicating HPTLC Method for Simultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets. International Journal of Pharmaceutical and Pharmac Science. 4(4); 2012: 468-471.
- Singh S, Patel K, Agarwal VK, Chaturvedi S. Simultaneous estimation of S(-) Amlodipine Besylate Hemipentahydrate and Losartan Potassium in Combined Dosage Form by Using UVSpectroscopy. Scholar Research Library. 4(3); 2002: 897-905.
- Singh S, Yadav AK, Gautam H. First Order Derivative Spectrophotometric Determination of Telmisartan in Pharmaceutical Formulation. Bulletin of Pharmaceutical Research. 2(2); 2012: 83-86.
- Singh S, Dubey N, Jain DK. Simultaneous estimation of cefpodoxime proxetil and clavulate potassium combined dosage form using UV-Spectroscopy and reverse phase liquid chromatography. International Journal of Pharmaceutical and Biomedical Science. 5(1); 2011: 57-60.
- Patel K, Singh S, Sahu P, Trivedi P. Development and validation of stability indicating assay method for naratriptan by ultra performance liquid chromatography. Scholar Research Library. 3(6); 2011: 102-107.
- Singh S, Yadav AK, Gautam H. Simultaneous Estimation of Valsartan and Hydrochlorothiazide in Solid Dosage Form Using UV Spectroscopy. Bulletin of Pharmaceutical Research. 1(3); 2011: 10-12.
- Singh S, Dubey N, Jain DK. Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage forms using UV-Spectroscopy. Asian Journal of Research and Chemistry. 3(4); 2010: 885-887.