Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Ahmad, Wajid
- A Comprehensive Review on Microspheres
Abstract Views :85 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
1 Department of Pharmaceutics, Institute of Pharmacy, Ankara, TR
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 136-140Abstract
Microspheres are typically free flow powders consisting of proteins or synthetic polymers which are biodegradable in nature. And ideally having a particle size less than 200μm. Microsphere after ball bearing effects because of their spherical shape. The therapeutic efficacy of microspheres contain drug depends upon their characteristics that can be altered in required terms by altering materials, methods, polymers or techniques used. A Microspheres has its drug dispersed throughout the particle i.e. the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs to the tumor. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.Keywords
Microspheres, Drug Delivery, Target Site, Preparation, Evaluation, ApplicationReferences
- Kawaguchi H. Functional polymer microspheres. Progress in polymer science. 2000 Oct 1;25(8):1171-210.
- Freiberg S, Zhu XX. Polymer microspheres for controlled drug release. International journal of pharmaceutics. 2004 Sep 10;282(1-2):1-8.
- O'Donnell PB, McGinity JW. Preparation of microspheres by the solvent evaporation technique. Advanced drug delivery reviews. 1997 Oct 13;28(1):25-42.
- Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. Journal of controlled release. 2003 Jul 31;90(3):261-80.
- Anderson JM, Shive MS. Biodegradation and biocompatibility of PLA and PLGA microspheres. Advanced drug delivery reviews. 1997 Oct 13;28(1):5-24.
- Mateus AY, Barrias CC, Ribeiro C, Ferraz MP, Monteiro FJ. Comparative study of nanohydroxyapatite microspheres for medical applications. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 2008 Aug;86(2):483-93.
- Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. International journal of pharmaceutics. 2004 Apr 15;274(1-2):1-33.
- Okada H, Toguchi H. Biodegradable microspheres in drug delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems. 1995;12(1).
- Scheffel U, Rhodes BA, Natarajan TK, Wagner HN. Albumin microspheres for study of the reticuloendothelial system. Journal of Nuclear Medicine. 1972 Jul 1;13(7):498-503.
- Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Bassett M, Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature. 1997 Mar;386(6623):410-4.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- Wei W, Wang LY, Yuan L, Wei Q, Yang XD, Su ZG, Ma GH. Preparation and application of novel microspheres possessing autofluorescent properties. Advanced Functional Materials. 2007 Nov 5;17(16):3153-8.
- Senyei A, Widder K, Czerlinski G. Magnetic guidance of drug‐carrying microspheres. Journal of Applied Physics. 1978 Jun;49(6):3578-83.
- Saralidze K, Koole LH, Knetsch ML. Polymeric microspheres for medical applications. Materials. 2010 Jun;3(6):3537-64.
- Kim KK, Pack DW. Microspheres for drug delivery. InBioMEMS and biomedical nanotechnology 2006 (pp. 19-50). Springer, Boston, MA.
- Benoit JP, Faisant N, Venier-Julienne MC, Menei P. Development of microspheres for neurological disorders: from basics to clinical applications. Journal of Controlled Release. 2000 Mar 1;65(1-2):285-96.
- Buckberg GD, Luck JC, Payne DB, Hoffman JI, Archie JP, Fixler DE. Some sources of error in measuring regional blood flow with radioactive microspheres. Journal of applied physiology. 1971 Oct;31(4):598-604.
- Denkbaş EB, Kilicay E, Birlikseven C, Öztürk E. Magnetic chitosan microspheres: preparation and characterization. Reactive and Functional Polymers. 2002 Feb 1;50(3):225-32.
- Eldridge JH, Staas JK, Meulbroek JA, McGhee JR, Tice TR, Gilley RM. Biodegradable microspheres as a vaccine delivery system. Molecular immunology. 1991 Mar 1;28(3):287-94.
- Varde NK, Pack DW. Microspheres for controlled release drug delivery. Expert opinion on biological therapy. 2004 Jan 1;4(1):35-51.
- Malviya V, Thakur Y, Shrikhande S, Gudadhe K, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres. Pharmaceutical research. 2008 Aug;25(8):1815-21..
- Häfeli UO, Pauer GJ. In vitro and in vivo toxicity of magnetic microspheres. Journal of magnetism and magnetic materials. 1999 Apr 1;194(1-3):76-82.
- Benner RE, Barber PW, Owen JF, Chang RK. Observation of structure resonances in the fluorescence spectra from microspheres. Physical Review Letters. 1980 Feb 18;44(7):475.
- Vengadesh PK, Sundaramoorthi C, Selvaraju K, Karthick K, Beena KP. Preparation and Characterization of Chitosan Microspheres Containing a Model Antigen. Research Journal of Pharmacy and Technology. 2011;4(10):1630-2.
- Venkateswaramurthy N, Sambathkumar R, Vijayabaskaran M, Perumal P. Preparation and Evaluation of Mucoadhesive Microspheres Containing Heparin for Antiulcer Therapy. Research Journal of Pharmacy and Technology. 2011;4(2):268-70.
- Saravanakumar A, Minz S, Pradhan M, Sure P, Chandu AN, Mishra U, Kamalakannan K, Sivakumar T. Polylactic acid microspheres as a potential vaccine delivery system for the tetanus toxoid: Preparation and in vitro dissolution study. Research Journal of Pharmacy and Technology. 2008;1(4):453-9.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Kalaivani M, Pulikottil MJ, Mary BM, Sakthivel R, Rajasekaran A. Preparation and Characterisation of Alginate Coated Chitosan Microspheres for Bacterial Vaccines. Research Journal of Pharmacy and Technology. 2010;3(2):503-6.
- SP S, KL S. Preparation and In-Vitro evaluation of Abacavir Sulphate loaded microspheres cross-linked by different concentrations of glutaraldehyde. Research Journal of Pharmacy and Technology. 2010;3(4):1128-31.
- Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
- Mali SD, Khochage SR, Nitalikar MM, Magdum CS. Microencapsulation: a review. Research Journal of Pharmacy and Technology. 2013;6(9):954-61.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH. 2021 Jan 1;55(1):86-94.
- Jain AA, Panigrahy RN, Mahale AM. Formulation and Evaluation of Extended Release Metformin Hydrochloride Microspheres by Ionotropic Gelation Technique. Research Journal of Pharmacy and Technology. 2011;4(7):1055-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Shinde AD, Bhise SB. Development and Optimization of Mucoadhesive Microsphere of Bovine Insulin. Research Journal of Pharmacy and Technology. 2010;3(2):604-9.
- Patil UK, Sahu R, Yadav SK. Formulation and Evaluation of Controlled Release Microspheres Containing Metformin Hydrochloride. Research Journal of Pharmacy and Technology. 2009 Mar 28;2(1):176-9.
- Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec;45(1):1-3.
- Gupta R, Prajapati SK, Bhardwaj P, Chaurasia H. In-Vivo Evaluation of Glipizide Floating Micropheres. Research Journal of Pharmacy and Technology. 2009;2(3):474-6.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019 Dec 30;12(12):5972-6.
- Kulkarni AD, Bari DB, Surana SJ, Pardeshi CV. In vitro, ex vivo and in vivo performance of chitosan-based spray-dried nasal mucoadhesive microspheres of diltiazem hydrochloride. Journal of Drug Delivery Science and Technology. 2016 Feb 1;31:108-17.
- Caruso F, Caruso RA, Möhwald H. Production of hollow microspheres from nanostructured composite particles. Chemistry of materials. 1999 Nov 15;11(11):3309-14.
- Crotts G, Park TG. Preparation of porous and nonporous biodegradable polymeric hollow microspheres. Journal of Controlled Release. 1995 Aug 1;35(2-3):91-105.
- Chang MW, Stride E, Edirisinghe M. A new method for the preparation of monoporous hollow microspheres. Langmuir. 2010 Apr 6;26(7):5115-21.
- Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. Journal of pharmaceutical sciences. 1992 Feb 1;81(2):135-40.
- Arshady R. Microspheres for biomedical applications: preparation of reactive and labelled microspheres. Biomaterials. 1993 Jan 1;14(1):5-15.
- An Updated Review on Preparation and Characterization of Solid Lipid Nanoparticles
Abstract Views :70 |
PDF Views:0
Authors
Wajid Ahmad
1,
Rihan Jawed
1
Affiliations
1 Department of Pharmaceutics, Institute of Pharmacy, Angola, TR
1 Department of Pharmaceutics, Institute of Pharmacy, Angola, TR
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 313-319Abstract
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage. Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. Appropriate analytical techniques for the characterization of SLN like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers are also discussed.Keywords
SLM, Production Technique, Lipid Based Carrier, Pharmaceutical ApplicationReferences
- Sachin J, Gupta NV. Solid lipid nanoparticles–preparation, applications, characterization, uses in various cancer therapies: a review. Research Journal of Pharmacy and Technology. 2013;6(8):825-37.
- Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
- Malviya V, Manekar S. Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo Co-Agglomeration technique. Evaluation. 2021 Mar 1;1(1):1.
- Mulla JA, Suresh S, Khazi IA. Formulation, characterization and in vitro evaluation of methotrexate solid lipid nanoparticles. Research Journal of Pharmacy and Technology. 2009;2(4):685-9.
- Nachammai K, Nair KG, RamaiyanVelmurugan SK. Sustained–Release study on Mefenamic acid and Mosapride loaded solid lipid Nanoparticles: In vitro Characterization. Research Journal of Pharmacy and Technology. 2020 Nov 13;13(11):5391-5.
- Gholse YN, Yeole MP. Microencapsulation for the therapeutic delivery of Proteins and other drugs: Update and future challenges. Research Journal of Pharmacy and Technology. 2013;6(5):465-76.
- Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28;15(1):5782-93.
- Patel D, Prajapati ST, Patel CN, Patel J, Savan V. A Review on Insoluble Drug Delivery Technology. Research Journal of Pharmacy and Technology. 2010;3(2):333-8.
- Dhiman S, Singh TG, Anand S, Yadav P. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021 May 26;14(5):2548-56.
- Veni DK, Gupta NV. Quality by Design approach in the development of Solid Lipid Nanoparticles of Linagliptin. Research Journal of Pharmacy and Technology. 2019;12(9):4454-62.
- Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
- Hou D, Xie C, Huang K, Zhu C. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials. 2003 May 1;24(10):1781-5.
- Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Advanced drug delivery reviews. 2012 Dec 1;64:83-101.
- Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. European journal of pharmaceutics and biopharmaceutics. 2000 Jul 3;50(1):161-77.
- Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
- Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
- Üner M, Yener G. Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. International journal of nanomedicine. 2007 Sep;2(3):289.
- Morel S, Ugazio E, Cavalli R, Gasco MR. Thymopentin in solid lipid nanoparticles. International journal of pharmaceutics. 1996 Apr 30;132(1-2):259-61.
- Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
- Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Advanced pharmaceutical bulletin. 2015 Sep;5(3):305.
- Tiyaboonchai W, Tungpradit W, Plianbangchang P. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 2007 Jun 7;337(1-2):299-306.
- Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of TeneligliptinHydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
- zurMühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. European journal of pharmaceutics and biopharmaceutics. 1998 Mar 1;45(2):149-55.
- Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.