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Verma, Vikas Kumar
- Beating Cancer with Natural Plant Sources
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Authors
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1 Saroj Institute of Technology & Management, Ahimamau , P.O. Arjunganj , Sultanpur Road, Lucknow-226002, Uttar Pradesh, IN
1 Saroj Institute of Technology & Management, Ahimamau , P.O. Arjunganj , Sultanpur Road, Lucknow-226002, Uttar Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 2 (2013), Pagination: 39-44Abstract
Medicinal plants continue to play a central role in the healthcare system of large proportions of the world's population. This is particularly true in developing countries, where herbal medicine has a long and uninterrupted history of use. Continuous usage of herbal medicine by a large proportion of the population in the developing countries is largely due to the high cost of Western pharmaceuticals and healthcare. Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Specific part of it is formulated into suitable preparations compressed as tablets or made into pills, used to make infusions, extracts, tinctures, etc., or mixed with excipients to make lotions, ointments, creams, etc. Few herbal drugs are subject to legislative control. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide, S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin, 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears), silymarin (milk thistle), anethol, catechins, eugenol, indole-3-carbinol, limonene, beta carotene, and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action.Keywords
Herbal Medicine, Pharmaceuticals, Healthcare, Infusions, Extracts, Tinctures, Anticancer AgentsReferences
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- Ancuceanu, R.V., Istudor, V., (2004). Pharmacologically active natural compounds for lung cancer. Altern Med Rev.,9: 402-419.
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- Okouneva, T., Hill, B.T., Wilson, L., Jordan, M.A., (2003). The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol Cancer Ther.,2: 427-436
- Cymbopogon Citrates Oil Showing Antimicrobial Activity against Microbes of Environmental, Clinical and Food Origin
Abstract Views :424 |
PDF Views:2
Authors
Affiliations
1 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh
2 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh, IN
1 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh
2 Saroj Institute of Technology & Management, Ahimamau P.O. Arjunganj Sultanpur Road, Lucknow-226002,Uttar Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 2 (2013), Pagination: 67-72Abstract
Out of the 1114 strains belonging to 29 genera and 105 species of microbes (molds, yeasts and bacteria) isolated from different sources [clinical cases, environment (water, air, soil, droppings of lizards and birds), food and healthy animals], 38.2% were sensitive to lemongrass oil discs containing 50 μg oil/disc. All molds, yeasts, Lactobacillus acidophilus, Morganella morganii, most of the Bacillus spp. Strains (84.3%), aeromonads (78%), Edwardsiella spp. (73.9%), 53.6% pseudomonads, 53.1% streptococci and 50% of Budvicia aquatica and Leminorella ghirmontii strains were sensitive to lemongrass oil (LGO). On the other hand, all Hafnea alvei, Laclercia adecarboxylata, Xenorhabdus luminescens and majority of Salmonella enterica (98.3%), Citrobacter spp. (93.7%), Providencia spp. and Kluyvera cryocrescens (83.3%), Enterobacter spp. (78.2%), Proteus spp. (78%), Escherichia spp. (77.7%), enterococci (73.7%), Serratia spp. (75%) and Erwinia ananas (75%), Pragia fontium (70.6%), staphylococci (69.8%) and Klebsiella spp. (62.7%) strains were resistant to LGO. MIC of LGO for sensitive strains (tested against discs containing 50 μg LGO) varied from 1 μg to 32 μg /ml while none of the resistant strains had MIC <64 μg LGO/ ml. MIC for yeast strains was the least i.e., 1 μg LGO/ ml. LGO had microbicidal activity on E. coli, S. aureus and Candida albicans. LGO instantly killed C. albicans and E. coli, and S. aureus in 10 min at 1 mg/ ml concentration, indicating of its wide spectrum antimicrobial activity at easily achievable concentrations. Study also indicated that LGO is more effective on enterococci in aerobic instead of microaerophilic growth conditions, it is indicative that in-vivo sensitivity results may differ from in-vitro tests.Keywords
Lemongrass Oil, Antimicrobial Activity, Microbes, Microaerophilic GrowthReferences
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