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Debnath, Subhashis
- Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride
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Authors
Affiliations
1 Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
3 Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, IN
1 Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
3 Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 9-15Abstract
Terbinafine hydrochloride is a synthetic antifungal drug. It is slightly soluble in water (3mg/ml) and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore solid dispersion of terbinafine HCl with polyethylene glycol-6000 (PEG 6000) and mannitol were prepared with a view to increase its water solubility. In this study solid dispersion of the drug were prepared by melting method and the drug was taken with carrier in the proportions of (1:1, 1:2 and 1:3). The rate of dissolution of terbinafine HCl was increased with the proportion of (1:3) (Drug: PEG 6000) when compared to the other formulations. In order to predict and correlate the release behavior of the drug from the polymer matrix the dissolution data were fitted in to a suitable model to describe the drug release behavior from polymeric system. The surface morphology of the prepared solid dispersion and drug alone were examined by SEM analysis. The SEM result shows that in the case of solid dispersion of terbinafine HCl, particles were in almost amorphous form, which indicates a reduction in particle size.Keywords
Antifungal, Bioavailability, Solid Dispersion, Polymer Matrix, SEM
References
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- Formulation and Development of a Compression Coated, Matrix Based, Tablet of Verapamil HCl using Design of Experiments
Abstract Views :333 |
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Authors
Affiliations
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, IN
2 Department of Pharmaceutics, J S S College of Pharmacy, Ooty-643001, A.P, IN
1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupati-517561, A.P, IN
2 Department of Pharmaceutics, J S S College of Pharmacy, Ooty-643001, A.P, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 3 (2017), Pagination: 117-126Abstract
Compression coating provides a unique platform for formulating modified release products in a way the dosage form can successfully be targeted to localize the release of the drug in any desired portion of the GIT without the additional step of film coating. The current work focuses on the development and optimization of modified release Verapamil Hydrochloride tablets using compression coating. The effect of various concentrations of different grades HPMC polymers, like, K4M, K15M and K100M on the release profile was studied in DOE environment. The results of the DOE provide an optimized range of the three polymers which could potentially give the targeted release profile for all drugs which have solubility profiles similar to Verapamil HCl. Three batches of optimized formulation were loaded on to accelerated stability studies at 40° C/75% RH in HDPE containers and the 3 months stability data indicates that there is no significant change in either the potency of the dosage form or its in vitro dissolution profile.Keywords
Verapamil, DOE, HPMC, Formulation.References
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- Coronavirus Disease (COVID-19): A Global Threat
Abstract Views :361 |
PDF Views:0
Authors
Affiliations
1 Royal School of Pharmacy, The Assam Royal Global University, Guwahati, Assam, IN
1 Royal School of Pharmacy, The Assam Royal Global University, Guwahati, Assam, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 1 (2022), Pagination: 63-69Abstract
Coronavirus (CoVs) is a type of enveloped RNA virus that is found in animals and humans. There are near about six different species of CoVs are available and all of them can cause different health issue to human. In human this virus can effect respiratory, hepatic, enteric and neurological system. The past Middle East respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus has been transmitted from animal to human. Presently there is a new strain of corona virus, named SARS-CoV-2, causing serious health crises to human. This virus is highly contagious and has resulted in a rapid pandemic of COVID-19. The number of infected people and death caused by COVID-19 is increasing day by day. This review will provide a detailed overview of COVID-19 and its serious effect to the human health.Keywords
Coronavirus, Virus, Health, SARS-CoV-2References
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