Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Thennarasan, Sathyaseelan
- Antidiabetic Efficacy of Methanol Extract Brown Alga Lobophora variegata on Alloxan Stimulated Hyperglycemic Wistar Albino Rats
Abstract Views :194 |
PDF Views:0
Authors
Affiliations
1 Division of Algal Biotechnology and Bionano Technology, Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 Research Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
1 Division of Algal Biotechnology and Bionano Technology, Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 Research Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 3 (2017), Pagination: 157-165Abstract
To investigate the effect of methanol extract of Lobophora variegata for its antihyperglycemic activity against alloxan induced diabetic rats. The methanol residue of Lobophora variegata was given orally at a dosage of 10 mg/kg weight to diabetic animals for about 28 days. The outcome of algae residue feeding was estimated by various biochemical and haematological parameters such as RBC, WBC, HB and platelets and lipid profile. Histopathological evaluation was made in the pancreas. After feeding of methanol extract in diabetic rats for 28 days, the blood glucose has significantly decreased, while the increase in liver glycogen level was observed. In addition, the regeneration of the pancreas of the treated animals was also noticed. The methanol residues of the Lobophora variegata possess very effective anti-hyperglycemic activity on the diabetic rats as compared to Glipizide.Keywords
Lobophora variegata, Alloxan Monohydrate, Carbohydrate Metabolism, Diabetes Mellitus, Brown Algae.
References
- Kaleem M, Medha P, Ahmed QA, Asif M, Bano B. Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2008; 49: 800–804.
- Sunil C, Latha PG, Suja SR, Shine VJ, Shyamal S, Anuja GI, et al. Effect of ethanolic extract of Pisonia alba Span. leaves on blood glucose levels and histological changes in tissues of alloxan-induced diabetic rats. Int J Appl Res Nat Prod. 2009; 2: 4–11.
- Maiti A, Dewanjee S, Jana G, Mandal SC. Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes. Int J Green Pharm. 2008; 2: 224–227.
- Sunil C, Latha G, Mohanraj KP, Kalichelvan V, Agastian P. α-Glucosidase inhibitory and antidiabetic activities of ethanolic extract of Pisonia alba Span. leaves. Int J Integr Biol. 2009; 6: 41–45.
- Sharifuddin Y, Chin YX, Lim PE, Phang SM. Potential bioactive compounds from seaweed for diabetes management. Marine Drugs 2015; 13: 5447–5491.
- Liu X, Li X, Gao L, Cui C, Li C, Li J, Wang B. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula. Chinese. Journal. Oceanology. Limnology. 2011; 29: 686–690.
- Shi D, Guo S, Jiang B, Guo C, Wang T, Zhang L, Li J. HPN, a synthetic analogue of bromophenol from red alga Rhodomelaconfervoides: Synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice. Marine. Drugs 2013; 11: 350–362.
- Kim KY, Nam KA, Kurihara H, Kim SM. Potent α-glucosidase inhibitors purified from the red algae Grateloupiaelliptica. Phytochemistry. 2008; 69: 2820–2825.
- Murugesan S, Bhuvaneswari S, Sivamurugan V. In vivo antidiabetic efficacy of red algae Portieriahornemannii and Spyridiafusiformis methanol extract on alloxan stimulated hyperglycemic activity in wistar albino rats. Saudi J. Med. Pharm. Sci. 2016; 2: 282-290.
- Kang C, Jin YB, Lee H, Cha M, Sohn E-T, Moon J, Park C, Chun S, Jung E-S, Hong J-S. Food Chem. Toxicol. 2010; 48: 509–516.
- Iwai K. Antidiabetic and antioxidant effects of polyphenols in brown alga Eckloniastolonifera in genetically diabetic KK-A(y) mice. Plant Foods Hum.Nutr.2008; 63:163–169.
- Nwosu F, Morris J, Lund VA, Stewart D, Ross HA, McDougall GJ. Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae. Food Chemistry. 2011; 126: 1006–1012.
- Thomas NV, Kim SK. Potential pharmacological applications of polyphenolic derivatives from marine brown algae. Environ. Toxicol. Pharmacol. 2011; 32: 325–335.
- Heo SJ, Hwang JY, Choi JI, Han JS, Kim HJ, Jeon YJ. Diphlorethohydroxycarmalol isolated from Ishigeokamurae, a brown alga, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur. J. Pharmacol. 2009; 615: 252–256.
- Celikler S, Tas S, Vatan O, Ziyanok-Ayvalik S, Yildiz G, Bilaloglu R. Anti-hyperglycemic and antigenotoxic potential of Ulvarigidaethanolic extract in the experimental diabetes mellitus. Food Chem. Toxicol. 2009; 47: 1837–1840.
- Popov AM, Krivoshapko ON. Protective effects of polar lipids and redox- active compounds from marine organisms at modeling of hyperlipidemia and diabetes. J. Biomed. Sci. Eng. 2013; 6: 543–550.
- Suzen S, Buyukbingol E. Recent studies of aldose reductase enzyme inhibition for diabetic complications. Current. Medicinal. Chemistry. 2003; 10: 1329–1352.
- Al-Shamaony L, Al-Khazraji SM, and Twaij HA. Hypoglycaemic effect of Artemisia herbaalba. II. Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology.1994; 43(3): 167-171.
- Trinder P. Determination of blood glucose using an oxidaseperoxidase system with a noncarcinogenic chromogen. Journal of clinical pathology.1969; 22(2): 158-161.
- Crane RK, Sols OA. Animal tissue hexokinase. In: Colowick S P. Kaplan. (eds) Methods in Enzymology.2nd edition, Academic Press, New York. 1955; pp. 277–282.
- Fiske C H, and Subbarow Y. The colorimetric determination of phosphorus. J. biol. Chem, 1925; 66(2): 375-400.
- Morales M A, Jabbagy A J, and Tenenzi H P. Mutation affecting accumulation of glycogen. Neurospora News Lett. 1973; 20:24– 25.
- Tang LQ, Wei W, Chen LM, and Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. Journal of Ethnopharmacology, 2006; 108(1): 109-115.
- Li QG, Sun R, and Gao FZ. Effect of Shen Di Jiang Tang granules on diabetic rats. China Journal of Chinese Materia Medica, 2001; 26: 488-490.
- Akpan HB, Adefule AK, Fakoya FA, Caxton martins EA. Evaluation of LDH and G6- PDH activities in auditory relay centers of streptozotocin-induced diabetic wistar rats. J Analyt Sciences 2007; 1:21-25.
- Welihinda J, Karunanayake EH. Extra-pancreatic effects of Eugenia jambolana in rats. J Ethno Pharmacology 1986; 17: 247–255.
- Lolitkar MM, Rao MRR. Pharmacology of a hypoglycemic principle isolated from the fruits of Eugenia jambolana Linn. Ind J Pharm 1966; 28: 129–133.
- Alberti KGMMM. Press, In: Keen, Hand J. Javve (Eds.) The Biochemistry and the Complication of Diabetes. Edward Arnold Publishers.1982; 231-270.
- Sheela CG, Augusti KT. Antidiabetic effects of garlic, Allium sativum Linn. Ind. J. Exp. Biol. 1992; 30: 523-526.
- Shirwaikar A, Rajendran K, Kumar CD, Bodla R. Antidiabetic activities of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J Ethnopharmacol. 2004; 91: 171–175.
- Lawrence JC, Roach PJ. New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes. 1997; 46: 541–547.
- Bouche C, Serdy S, Kahn CR, Goldfine AB. The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev. 2004; 25: 807–830.
- Feillet-Coudray C, Rock E, Coudray C. Lipid peroxidation and antioxidant status in experimental diabetes. ClinChimActa.1999; 284: 31–43.
- Hunt J, Dean RT, Wolff SP. Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes and ageing. Biochem J. 1988; 256: 205–212.
- Levin, W., Lu, A.Y., Jacobson, M., Kuntzman, R., Poyer, J.L and McCay, P.B.1973. Lipid peroxidation and the degradation of cytochrome P-450 heme. Arch Biochem Biophys.158:842–852.
- Selvam R, Anuradha CV. Effect of oral methionine on blood lipid peroxidation. Nutr Biochem. 1990; 1: 653–665.
- Stanely MPP, Menon VP. Antioxidant action of Tinospora cordifolia ischolar_main extract in alloxan diabetic rats. Phytother Res. 2001; 5: 213–218.
- Hikino, H., Kobayashi, M., Suzuki, Y and Konno, C. 1989 Mechanism of hypoglycemic activity of aconitan A, a glycan from Aconitum carmichaeli ischolar_mains. J Ethno Pharmacol. 25 (3): 295–304.
- Day C, Catwright T, Provost J, Bailey CJ. Hypoglycaemic effect of Momordica charantia extracts. Planta Med, 1990; 56: 426– 429.
- Gray AM, Flatt PR. Insulin-releasing and insulin like activity of Agaricusc ampestris (mushroom). J Endocrinol, 1998; 157: 259– 266.
- Yadav UCS, Moorthy K, Baquer NZ. Combined Treatment of Sodium orthovanadate and Momordic acharantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Mol. Cell. Biochem.2005; 268: 111–120.
- Chakrabarti S, Biswas TK, Rokeya B, Ali L, Mosihuzzaman Nahar N, Azad khan AK, Mukherjee B. Advanced studies on the hypoglycemic effect of Caesalpinia bonducella F. in type 1 and 2 diabetes in long Evans rats. J Ethnopharmacol.2003; 84: 41-46.
- Campos KE, Diniz YS, Cataneo AC, Faine LA, Alves MJQF, Novelli ELB. Hypoglycemic and antioxidant effects of onion, Allium cepa: dietary onion addition, antioxidant activity and hypoglycemic effects on diabetic rats. Int J Food Sci Nutr. 2003; 54: 241-246.
- Laakso M. Epidemiology of diabetic dyslipidaemia. Diabetes Rev 1995;3: 408-422.
- Taskinen MR, Beltz WF, Harper I. Effects of NIDDM on very-low-density lipoprotein, triglyceride and apolipoprotein B metabolism. Studies before and after sulfonylurea therapy. Diabetes.1986; 35: 1268-1277.
- Segal P, Bachorik PS, Rifaind BM, Levy R. Lipids and dyslipoproteinemia. Clinical Diagnosis and Management. 1984; 80-203.
- Gordon T, Castelli WP, Hjortl and MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease: the Framingham study. Am J Med. 1977; 62: 707– 714.
- Pushparaj P, Tan CH, Tan BK. Effects of Averrhoabi limbi leaf extract on blood glucose and lipids in streptozotocin induced diabetic rats. J. Ethnopharmacol. 2000; 72: 69-76.