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Mohite, S. K.
- Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride
Authors
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 3 (2016), Pagination: 183-185Abstract
Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. This review gives a view of advantages, limitations, need for formulating FDTS, Formulation factors, excipients used, and methodology and evaluation parameters.
Fast dissolving tablets (FDTs) can be prepared by different methods, such as direct compression, freeze-drying, spray drying, sublimation, wet granulation method4. The basic approach for the development of FDTs is the use of superdisintegrants. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent as well as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants, like microcrystalline cellulose. Tramadol hydrochloride, a centrally acting synthetic opioid analgesic, was selected as the active pharmaceutical ingredient in the study.
Keywords
Tramadol Hydrochloride, Direct Compression Method, Microcrystalline Cellulose.- Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery
Authors
1 Department of Quality Assurance, Rajarmbapu College of Pharmacy, Kasegaon, Dist: Sangli, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 91-96Abstract
The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Itraconazole. Emulgel formulations of Itraconazole were prepared using two types of gelling agents namely: Carbopol 934 and Carbopol 940. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using a 23 factorial design. The prepared formulations were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, transmission electron microscopy and stability. Commercially available Itraconazole cream was used for comparison. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The antifungal activity and drug release were found to be higher for optimized formulation as compared to the marketed Itraconazole cream. The result of studied revealed that the optimized batch shows 95.08% release in 48 hours and stable for around three. The result of microbial assay compared with marketed product, the result shows46.6% inhibition of optimized batch where as marketed preparation shows only 32.3% inhibition. While result of skin irritation test shows no edema and erythema. No irritation was observed on the skin of the rabbits. Stability studies showed that the physical appearance, rheological study, in vitro drug release, and antifungal activity in all the prepared emulgel remained unchanged upon storage for 3 months. In general conclusion, it was suggested that the emulgel formulation succeed the drug release for sustained drug delivery in a controlled manner in comparison with cream.Keywords
Emulgel, Itraconazole.- Formulation and Characterization of fast Dissolving tablets of Perindopril
Authors
1 Rajarambapu College of Pharmacy, Kasegaon MS, IN