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Barhate, S. D.
- Evaluation of Binding Property of Remusatia vivipara (Roxb) Mucilage in Tablet Formulation
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Authors
Affiliations
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jammer, IN
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jammer, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 1 (2015), Pagination: 23-28Abstract
Remusatia vivipara is a common herbaceous belongs to the family of Araceae. Tubers of plant contain mucilage hence attempt to evaluate the tubers for suitability as tablet binder is considered and the present investigation repots the isolation of mucilage of Remusatia vivipara tubers. The DSC and FTIR thermograms of drug and mucilage indicated no chemical interaction. Phytochemical and Physiochemical characteristics of mucilage were studied which confirmed the mucilage nature. The mucilage was evaluated for its granulating and binding properties in compressed tablet using Metformin HCl as model drug. The granules prepared by mucilage with different concentration such as 1%, 3%, 5% and 10% were compared with starch paste, which was used as standard binder. The tablets had good physiochemical properties and the drug release was more than 95% within 24hr. It was observed that decreasing the concentration of mucilage increases hardness and the disintegration time. The tablet prepared using 1% and 3% shows drug release rate in sustained manner and that of standard binder 10% starch paste used for comparison. Remusatia vivipara mucilage could be used as a good binding agent at very low concentrations. This can be used for sustaining the drug release from tablets, since the prepared tablets produced a sticky film of hydration on the surface, which ultimately reduces drug release rate and hence it can be evaluated for its efficacy to sustain the drug release.Keywords
Remusatia vivipara, Mucilage, Binder.
- Formulation Optimization and Evaluation of Push Pull Osmotic Pump Tablet of Vildagliptin
Abstract Views :67 |
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Authors
Affiliations
1 Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Dist - Jalgaon, Maharashtra, 424206, IN
2 Medley Pharmaceuticals Ltd., Andheri (East), Mumbai - 400 093, Maharashtra, IN
1 Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Dist - Jalgaon, Maharashtra, 424206, IN
2 Medley Pharmaceuticals Ltd., Andheri (East), Mumbai - 400 093, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 207-212Abstract
Purpose- The present study was to develop an oral push-pull osmotic pump tablet of vildagliptin, DPP-IV inhibitor drug; which is BCS class I drug. Method- The tablets were prepared by the wet granulation method using polyox and osmotic agent NaCl. The granules were compressed into bilayered tablet by conventional compression machine. The bilayered core osmotic tablets were coated with cellulose acetate in a conventional pan coating. In-vitro dissolution was evaluated using USP dissolution apparatus II in 0.1 N HCl pH 1.2 buffers for 2 hrs and phosphate buffer pH 7.5 for 22 hrs respectively. The formulated optimized batch VP1 were kept to stability studies for 3 months. Result- The formulated optimized batch VP1 of PPOP tablet shows 2hrs lag time with zero order release kinetic. In –vitro drug release was obtained 91.45 % up to 22hrs respectively. Polyox in push-pull layer along with osmotic agent and cellulose acetate controlled the drug release pattern from formulated PPOP tablet. No significant changes were observed upto the period of 3 months of storage during stability study. Conclusion- The PPOP tablet of vildagliptin was able to deliver the drug in controlled pattern over a long period of time by the process of osmosis. Conventional compression and pan coating method can be used to prepare PPOP tablet successfully.Keywords
PPOP, Bilayered Tablet, Polyox, Sodium Chloride, Vildagliptin, Cellulose Acetate, Factorial DesignReferences
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