Asian Journal of Pharmacy and Technology

S. K. Purohit ¹, R. Solanki ¹, R. Soni ¹, V. Mathur ¹

Affiliations
1 College of Veterinary and Animal Science, Rajasthan, IN

Abstract

Skin is the important organ of the human body as it plays a vital role in maintaining health of human being. Most of the diseases are caused by pathogenic microorganisms. Some of the most common causative microorganisms related with infections include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Wounds are major cause of physical disabilities. Wound healing consists of orderly progression of series of events that establish the integrity of the damaged tissues. Wound disease spread by the invasion of bacteria inside the body through skin. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Bacterial diseases are type of infectious diseases caused by pathogenic bacteria. Wound and skin infections represent the invasion of tissues by one or more species of microorganisms. These infections disturb the body immune system and causes inflammation, tissue damage and thus resulting in delayed wound healing process. Leaves of Azadirachta indica (Neem) are used for various medicinal purposes. It is useful in tiredness, cough, fever, loss of appetite, worm infestation. It heals wound, vomiting, skin diseases, heat-rash, boils, jaundice, leprosy, skin disorders, eye disorders, stomach ulcers, chicken pox, excessive thirst, diabetes and insect poisons. It act as anti-leprotic, antimalarial, anti-hemorrhoidal and anthelmintic agent. The present study was undertaken on evaluation of Azadirachta indica (Neem) leaves ethanolic extract for wound healing activity through topical route on excision wound model. The activity was compared with standard drug Povidone Iodine ointment (5% w/w). Azadirachta indica leaves ethanolic extract was found to have better and faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model. This article throws light on wound healing activity of ethanolic extract of Azadirachta indica leaves.

Keywords

Azadirachta indica,Povidone Iodine Ointment, Wound Healing Activity, Wound Contraction, Excision Wound Model

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R. Solanki ¹, B. P. Nagori ¹

Affiliations
1 Lachoo Memorial College of Science and Technology, Jodhpur, Rajasthan, IN

Abstract

Skin is the major organ of the human body which plays a vital role in maintaining health of human being. Certain diseases defined as infectious or communicable or transmissible diseases are caused by pathogenic microorganisms. Some of the most common causative microorganisms related with infections include Staphylococcus aureus, Streptococcus pyogenes, Enterococci, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Most of the diseases spread by the bacteria which invade inside the body through skin. Bacterial infections on skin are the common ailment for generation of other diseases in the body. Bacterial diseases are type of infectious diseases caused by pathogenic bacteria. Symptoms and complications related with bacterial infections such as chills, headache, wound, vomiting and organ failure generally affects the patient's life. Wound on skin can occur in all ages of persons and can causes harm in number of ways. Wound and skin infections represent the invasion of tissues by one or more species of microorganisms. These infections disturbs the body immune system and causes inflammation, tissue damage and thus resulting in delayed wound healing process. This article throws light on three aspects first on various types of microorganisms found responsible for causing wound infection on the skin, second on laboratory tests to diagnose the responsible microorganisms for wound infections and on choice of treatment for wound healing.

Keywords

Skin, Symptoms, Bacteria, Types of Wound Infection, Diagnostic Test, Antibiotics

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