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Authors
Affiliations
1 Department of Chemistry, Nandha College of Pharmacy and Research Institute, Erode-638052, Tamil Nadu, IN
Source
Asian Journal of Pharmacy and Technology, Vol 2, No 2 (2012), Pagination: 47-50
Abstract
The compounds of different Pyrazoline derivatives were synthesized by cyclization of substituted chalcone derivatives in presence of hydrazine hydrate (a-e). All the synthesized compounds were characterized by spectral analysis (IR, MS and NMR). The REMA (Resazurin Microtiter Assay) plate method was used for anti-tuberculosis activity. The minimum inhibitory concentration (MIC) of the newly synthesized compound was tested against Mycobacterium tuberculosis H37RV. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.
Keywords
Chalcone, Hydrazine Hydrate, Pyrazoline Derivatives, Characterization, Anti-Tuberculosis Activity.
