Asian Journal of Pharmacy and Technology

Vishal Mahanur ¹, Rahul Rajge ¹, Mukund Tawar ¹

Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604, IN

Abstract

The initial pass metabolism or pre-circulatory system is a metabolic process in which the concentration of the drug is significantly reduced or shortened in the liver before it reaches the circulatory system. A fraction of the drug lost in the entire absorption process is often associated with the liver and skin wall. Oral delivery, the simplest form of drug management has its limitations, most of which are the low availability of drugs due to the first internal organ passing through metabolism. Drugs with low bioavailability need to be administered at a better dose as a small fraction of the controlled dose is injected into the bloodstream and reaches the target. Therefore, the worst dose of the drug is destroyed and the unauthorized drug ends up having unwanted side effects within the canal. Various forms of oral contraceptives are used. The current review focuses on the importance of passing the first hepatic pass, the biological findings, the reasons for the negative findings and the various methods used to skip the initial hepatic pass metabolism.

Keywords

Hepatic First Pass Metabolism, Bioavailability, Novel Drug Delivery System, Low Bioavailability, Gut Wall, Site Targeted

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Kalyani Gudadhe ¹, Mukund Tawar ²

Affiliations
1 Department of Quality Assurance, P.R. Pote Patil College of Pharmacy, Amravati – 444604, IN
2 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604, IN

Abstract

A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1%. Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20μl.The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Rupatadine Fumarate were performed (10-60μg/ml). The %RSD for accuracy found to be less than 2%. Assay was found to be 99.17 to 101.65 respectively. The range of 10-60μg /ml was selected for the linearity of a standard Rupatadine Fumarate. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Rupatadine Fumarate was performed on (10-60μg/ml).

Keywords

RP-HPLC, Rupatadine Fumarate, Methanol, Ortho Phosphoric Acid

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Rahul Jodh ¹, Mukund Tawar ¹, Prashant Burange ¹, Vedanshu Malviya ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602, IN

Abstract

In The family Orchidaceae, The plant Dactylorhiza hatagirea (D.Don) Soo, is recognized worldwide for its multi-fold benefits. Dactylorhiza hatagirea (D.Don) Soo Traditionally it used to cure various diseases like dysentery, diarrhoea, chronic fever, cough, stomach-ache, wounds, cuts, burns, fractures, general weakness. Dactylorhiza hatagirea (D. Doon) Soo frequently known as Hatajari and Salampanja in the region of Himalaya. Dactylorhiza hatagirea (D. Doon) Soo is a terrestrial orchid found in moderate climate in the alpine and sub-alpine region Indian Himalaya from 2800-4200 m above from sea level its Occurrence also present in Pakistan, Afghanistan, Nepal, Tibet and Bhutan In India, it predominantly found in region of Jammu and Kashmir, Sikkim, Arunachal Pradesh, Uttarakhand and Himachal Pradesh. Dactylorhiza hatagirea (D. Doon) Soo is collected chaotically from nature due to its high economic demand. the plant consist of different active compound which are responsible for various activity attributed on the plant. the present review emphasis on pharmacological activity of Dactylorhiza hatagirea (D. Doon) Soo which is establish by different authors.

Keywords

Dactylorhiza hatagirea (D. Doon) Soo, Himalayan Orchid, Salam Panja, Metformin

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