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Authors
Affiliations
1 Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, Andhra Pradesh, IN
2 Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana, IN
3 Department of Pharmaceutical Analysis and QA, Teegala Ram Reddy College of Pharmacy,
Meerpet, Hyderabad-500097, Telangana, IN
4 Chaithanya College of Pharmacy, Markapur, Prakasham (Dist), A.P., IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 4 (2014), Pagination: 200-204
Abstract
The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Pseudoephedrine and Terfinadine tablets .The chromatographic separation was achieved on a Inertsil C18 ODS (4.6×250 mm, 5 μm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Pseudoephedrine and Terfinadine were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.
Keywords
RP-HPLC Method, Pseudoephedrine and Terfinadine, Tablet Dosage Forms, PDA Detection.
