Asian Journal of Pharmacy and Technology

Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD

Abstract

The sedimentation volume (F) is defined as the ratio of final or ultimate volume to the suspension volume. If the volume of sedimentation in a flocculated suspension equal to the original volume of suspension, then F=1 is pharmaceutically acceptable. When F=0 it means the total drug has sedimented and volume of sediment is negligible. So, more the volume of F more will be therapeutic acceptance. In this study two types of suspension were studied where aluminium hydroxide suspension classed as type-I and sodium-bi-carbonate, magnesium trisilicate, magnesium carbonate suspension classed as ty pe-II suspension. It was observed that the sedimentation volume is more in case of type-I suspension rather than type-II suspension.

Keywords

Sedimentation Volume, Aluminium Hydroxide, Sodium Bi Carbonate, Magnesium Trisilicate, Magnesium Carbonate.

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Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD

Abstract

The aerial part of Pouzolzia zeylanica (L.) Benn (fam. Urticaeae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Pouzolzia zeylanica which possess characters like greenish grey colour, characteristic odour and mucilaginous and slightly bitter taste. The fluorescence analysis under visible light and under UV light by treatment with different chemical reagents showed different colour changes. The presence of alkaloids, glycosides, tannins and flavonoids was confirmed during preliminary phytochemical screening.

Keywords

Organoleptic, Fluorescence, Phytochemical, Supernatant.

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Dibyajyoti Saha ¹, Swati Paul ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

The main objective of the present study was to determine the methanolic extract of Alpinia conchigera Griff for antifungal activity. To determine the antifungal activitiy agar disc diffusion method was used. The antifungal activity of the extracts was compared with standard drug Fluconazole (500 μg/disc). The methanol extract of Alpinia conchigera Griff showed very good antifungal activity ranging from zone of inhibition (7.0-26) mm and Aspergillus niger was the most susceptible fungal strain of the methanolic extract of Alpinia conchigera Griff. Due to these promising results, further in vivo studies over Alpinia conchigera Griff must be conducted.

Keywords

Alpinia conchigera Griff, Methanol Extract, Antifungal Activity.

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Dibyajyoti Saha ¹, Swati Paul ²

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD
2 Department of Pharmacy, BGC Trust University, Chittagong, IN

Abstract

Investigation with crude methanolic extract of Plumbago indica L. was carried out to evaluate its possible cytotoxic activity. Pharmacological history of this plant promoted us to check the possible cytotoxic activity. By using the brine shrimp lethality bioassay method, the LC50 and LC90 value of Plumbago indica L. was assayed. In this study, DMSO was used as solvent. The extract evidence cytotoxic activity against brine shrimp nauplii and calculated LC₅₀ and LC₉₀ value was 5.0μg/ml and 12 μg/ml respectively.

Keywords

Plumbago indica L. , Cytotoxicity, LC₅₀, Brine Shrimp Lethality Bioassay, LC₉₀.

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Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

The present study was designed to investigate Analgesic activity of methanolic extract of Plumbago indica (L.) using Acetic Acid Induced Writhing method. Methanolic extract was administered intraperitoneally at doses of 250 mg/kg and 500 mg/kg to Young Swiss-albino mice. Methanol Extract of Plumbago indica (L.) showed significant inhibition in pain response induced by thermal and mechanical stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.

Keywords

Plumbago indica (L.), Analgesic, Acetic Acid, Writhing Method.

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Swati Paul ¹, Dibyajyoti Saha ¹, Srikanta Chowdhury ²

Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD
2 Department of Biochemistry and Molecular Biology, University of Chittagong, BD

Abstract

The aerial part of Mimosa pudica (family: (Mimosaceae)) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Mimosa pudica which possess characters like deep green colour, characteristic odour and slightly bitter taste. The fluorescence analysis under visible UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Mimosa pudica indicate the presence of alkaloids, glycoloids, flavonoids, terpenoids, steroids, phlobatanins, tannins and saponins .The pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.

Keywords

Organoleptic, Phytochemical, Fluorescence, Mimosa pudica.

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Dibyajyoti Saha ¹, Swati Paul ¹

Affiliations
1 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, BD

Abstract

The aerial part of Tridax procumbens(family: Asteraceae) was studied to fix the parameters for pharmacognostical standards.The results of organoleptic study offer a scientific basis for the use of Tridax procumbens which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Tridax procumbens indicate the presence of Reducing sugars, Steroids, Alkaloids, Glycosides, Tannins, Flavonoids and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.

Keywords

Organoleptic, Fluorescence, Pharmacognostic Study.

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Dibyajyoti Saha ¹, Tarashankar Maity ², Mayukh Jana ³, Supradip Mandal ³

Affiliations
1 School of Pharmacy, Chouksey Engineering College. Lal Khadan, Masturi Road, Bilaspur-495004, C.G, IN
2 Calcutta Institute of Pharmaceutical Technology and A.H.S., Howrha-711316, W. B, IN
3 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN

Abstract

Cancer is any disorder of cell growth that results in invasion and destruction of surrounding healthy tissues by abnormal cells, which have arisen from normal cells, whose nature is permanently changed. The exact mechanism through which a normal cell is transform to a tumor cell is still not clear and is considered as very complex in nature comprising of several steps though in recent years considerable advancement in knowledge have been obtained in molecular mechanisms, growth regulatory factors, environmental effects, diet and food habits etc. Tumors that remain localized can usually be cured by surgery or radiotherapy even when enormous. Cancer, still regarded as the most progressive and dreadful disease, is posing a great social and economical problem globally since it has been estimated that in the year 2005 about 10.9 million new cases have been registered while about 6.7 million people had died from cancer while the respective figures for Indian people might be about 1 million of new incidences and 6 lakh of deaths. Data from USA showed that an estimated death of about 5.5 lakh had occurred in 20051. The number of new cancer cases is also increasing globally at a fast rate.

Keywords

Radiotherapy, Chemotherapy, Alkylating Agents, HDAC Inhibitor, Proteasome Inhibitors, Telomerase Inhibitor, Antiangiogenic Drugs, COX-2 Inhibitors.

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Dibyajyoti Saha ¹, Vibhor kumar Jain ¹, Bindu Jain ¹, Roshni Tandey ¹

Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan Masturi Road, Bilaspur - 495 004, C.G, IN

Abstract

Good laboratory practice is an essential part of good manufacturing practice detailed in Schedule M to the Drugs and Cosmetic rule. It involves a number of good practices in the QC laboratory which are to be undertaken to carry out an analysis with a defined degree of accuracy and precision. The importance of GLP is the implementation of GMP detailed in Schedule M cannot be overemphasized. The role of GLP is the development of quality test data, mutual acceptance of data avoids duplication of data, avoids technical barriers to trade and also protection of human health and the environment. The present article highlights important application of GLP in the design of accuracy, precision, reliability etc.

Keywords

Good Laboratory Practice, Quality Control, Quality Assurance.

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