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Authors
Affiliations
1 Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 59-65
Abstract
Mouth dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Mouth dissolving tablet of Astemizole was prepared by direct compression method using crosspovidone, Crosscarmellose and Indion 414, as superdisintegrants. Tablet was formulated by using different super disintegrants such as Crosscarmellose, Crosspovidone and Indion 414 in the ratio of 6%, 9% and 12% as represented by F1 to F9 respectively. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and In-vitro dissolution time. All the parameters were found to be within limits. The developed formulation of Astemizole batch F8 (9% Indion 414) showed good palatability and dispersed within 30 seconds as compared to crosscarmellose. In vitro dissolution study of Different Formulation with 9 % crosscarmellose sodium, crosspovidone and Indion 414 showed maximum dissolution rates with 81.32 %, 85.3 % and 95.48 % respectively of the drug released in 4 minutes. The best fitted model for the optimized formulation of F8 batch was found to be higuchi model. Higuchi model show the maximum release of drug having R value 0.996.
Keywords
Mouth Dissolving Tablets, Astemizole, Direct Compression Method, Higuchi Model, R Value.
