Asian Journal of Pharmacy and Technology

S. K. Sahu ¹, D. Das ², N. K. Tripathy ¹

Affiliations
1 Department of Zoology, Berhampur University, Berhampur, Odisha –760007, IN
2 School of Pharmaceutical Sciences, SOA University, Bhubaneswar, Odisha-754030, IN

Abstract

Ethanolic extract (80%) aerial part of Glinus oppositifolius was prepared and tested for its hepatoprotective effect against paracetamol-induced hepatitis in rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, cholesterol and bilirubin were tested in both treated and untreated groups. Paracetamol (2 g/kg) has enhanced the SGOT, SGPT, ALP, cholesterol and bilirubin levels. Treatment with ethanolic extract of aerial part of G. oppositifolius (200 mg/kg and 400 mg/kg) has reverse back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.

Keywords

Glinus oppositifolius, Hepatoprotective Activity, Paracetamol, Silymarin.

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