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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Adagaon, Nashik, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 27-30
Abstract
Flavones are the derivatives of flavonoids, possessing the wider range of biological actions. A series of flavonoid derivatives with the help of substituted benzaldehyde were synthesized and evaluated for antibacterial activity by cup-plate agar diffusion method. Out of six compounds 1-(2, 4- dihydroxyphenyl)-3-(4-(dimethyl amino) phenyl) prop-2ene-1one.(MCR-001) and 2-(4-(Di-methylamino) phenyl)-7-hydroxy-4-H-chromen-4-one. (MCR- 002), 2-hydroxy-2-(4-(methyl (4-nitrostyryl) amino) phenyl)-4-oxochroman-7-yl benzoate. (MCR-004) and 2-(4- dimethyl amino) phenyl)-4-oxo-4H-chromen-7-yl benzoate. (MCR-005) 2-(4-dimethyl amino) phenyl)-2- hydroxy 4-oxochroman-6-yl benzoate (MCR-005) have shown promising antibacterial activity also 7-hydroxy-2- (4-methyl (4-nitrostyryl) amino) phenyl)-4-H-chromen-4-one (MCR-003) ) and 2-(4-(4-chlorobenzyl) methyl) amino) phenyl)-2, 6-dihydroxychroman-4-one. (MCR-006) shown moderate antibacterial activity. This work has revealed the scope and potential of flavonoids for future exploration to synthesize substituted flavonoids and chalcone derivatives by the use of different substituted benzaldehyde.
Keywords
Flavonoid, Agar Diffusion Method, Antibacterial Activity.
