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Kshirsagar, Sanjay J.
- Computational Studies And Synthesis of Few Thiazolidine-2,4-Dion Analogues for Peroxisome Proliferator Activator Receptor- Γ Agonist as useful Antidiabetic Agent
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Nasik, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Nasik, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 4 (2017), Pagination: 265-268Abstract
Peroxisome proliferator activated receptor (PPAR)-γ is a member of the nuclear hormone receptor super family and the molecular target for the Thiazolidinediones (TZD), used clinically to treat insulin resistance in patients with type 2 diabetes. In addition to their efficacy to improve insulin sensitivity. Diabetes mellitus is a metabolic disease characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, proteins and lipids. The present work shows the rational design of some novel PPAR-γ agonists involving computational study performed by Molecular Design Suite (MDS) in to ligand binding domain of PPAR-γ receptor to explore conformations of molecules. The compounds synthesized using multi-step synthesis protocol. The purity of synthesized compound was ascertained by IR, NMR, Mass and elemental analysis and tested by oral glucose tolerance test (OGTT). Two molecules showed most prominent activity on hyperglycemic control.Keywords
Diabetic Mellitus, Thiazolidinedione, Computational Study.
References
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- Current Therapeutic Targets for Neuropathic Pain
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Authors
Khemchand R. Surana
1,
Abhijeet G. Parkhe
2,
Eknath D. Ahire
3,
Anuprita R. Pawar
1,
Survarna Khairnar
4,
Sunil K. Mahajan
5,
Dhananjay M. Patil
6,
Deepak D. Sonawane
6,
Sanjay J. Kshirsagar
3
Affiliations
1 Department of Pharmaceutical Chemistry, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
2 Bharati Vidhyapeeth College of Pharmacy, Belapur, Navi Mumbai, IN
3 Department of Pharmaceutics, MET’s, Institute of Pharmacy, BKC, Adgaon, Nashik – 3, IN
4 Department of Pharmacology, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
5 Department of Pharmaceutical Chemistry, MGV’s Pharmacy College, Panchvati, Nashik, IN
6 Department of Pharmaceutics, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
1 Department of Pharmaceutical Chemistry, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
2 Bharati Vidhyapeeth College of Pharmacy, Belapur, Navi Mumbai, IN
3 Department of Pharmaceutics, MET’s, Institute of Pharmacy, BKC, Adgaon, Nashik – 3, IN
4 Department of Pharmacology, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
5 Department of Pharmaceutical Chemistry, MGV’s Pharmacy College, Panchvati, Nashik, IN
6 Department of Pharmaceutics, Shreeshakti Shaikshanik Sanstha, Divine College of Pharmacy, Satana, Nashik, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 96 - 104Abstract
Nociceptive ache signals the frame to capability or real tissue harm. By contrast, neuropathic ache, which ends from damage or harm to the worried system, persists lengthy in spite of everything symptoms and symptoms of the authentic damage have disappeared. This kind of maladaptive ache affords a full-size scientific problem, because it responds poorly or unpredictably to classical analgesics. There is likewise no single, uniformly well- tolerated drug this is reliably helpful. Neuropathic ache withinside the popular populace is expected to have a occurrence ranging among 3% and 17%. Most of the remedies for neuropathic ache have slight efficacy and gift aspect consequences that restriction their use; therefore, different healing strategies are wished for patients. In this article, the contemporary trendy of care treatment, the rising pharmacological strategies until date, and the preclinical research on novel promising healing alternatives could be reviewed.
Keywords
Neuropathic pain, Inflammation, Drugs acting on neuropathic pain, Cannabinoid receptorReferences
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