Asian Journal of Pharmaceutical Research

Samir K. Shah ¹, Kruti M. Patel ¹, Pinal M. Vaviya ¹

Affiliations
1 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol, Anand, Gujarat, IN

Abstract

This study was aimed to evaluate the antiurolithiatic activity of alcoholic extract of Betula utilis in rats using ethylene glycol model. Standard drug used was Cystone. Healthy male Wistar rats weighing 180-200 g were selected. Ethylene glycol (0.75%) in drinking water was fed to all the groups (Groups II-VII) except normal control (Group I) for 28 days to induce urolithiasis for curative regimen (CR) and preventive regimen (PR). Groups III, IV served as CR and groups V, VI served as PR were treated with alcoholic extract of Betula utilis (250 and 500 mg/kg) Groups II and VII served as model control and standard (Cystone 750 mg/kg) respectively. Several parameters were used including urinary volume, urine pH, urine analysis, serum analysis, kidney homogenate and histopathology of kidney to assess the activity. The results indicated that the administration of alcoholic extract of Betula utilis to rats with ethylene glycol-induced lithiasis significantly reduced all the elevated biochemical parameters (calcium, phosphate, oxalate, creatinine, blood urea nitrogen and uric acid), restored the urine pH to normal and increased the urine volume significantly (p < 0.05) when compared to the model control. This study supports the usage of alcoholic extract of Betula utilis in urolithiasis.

Keywords

Betula utilis, Ethylene Glycol, Cystone, Urolithiasis.

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Kintu Patel ¹, Sankalp Patel ², Samir K. Shah ³

Affiliations
1 Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN
2 Dept. of Quality Assurance, Sardar Patel College of Pharmacy, Anand, IN
3 Principal, Dept. of Pharmacology, Sardar Patel College of Pharmacy, Anand, IN

Abstract

Iodine is a vital micronutrient required at all stages of life. It is concentrated in thyroid gland for the synthesis of thyroid hormones. Drinking water and crops grown in iodine rich soil are the most important sources of iodine. Leeching of iodine and ultra-violate radiation contribute to the development of iodine deficiency disorders (IDD). It mainly affects infant and children due to maternal iodine deficiency. A deficiency of thyroid hormone from any cause will lead to severe retardation of growth and maturation of almost all organ systems. In Asia, IDD is continuously increased from 4% to 50% among school children. Number of treatments are available for the IDD. However, the tribal population is considered to be one of the most disadvantaged groups in accessing the health care services and various other health policies. The Nashik based Neelvasant medical foundation & research centre established a new technique for the tribal women. They have made iodine patches in the form of different coloured bindis and distributed it among the tribal women. Around 80-90per cent of Indian women wear bindis. It is the best way to deal with the problem. The project is already started and ready to enter in its second phase. Where, larger number of population are covered.

Keywords

Iodine, Iodine Deficiency Disease (IDD), Iodine Patches, Lifesaving Dot.

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