Asian Journal of Pharmaceutical Research

S. J. Daharwal ¹, Veena D. Singh ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, IN

Abstract

A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215-225 nm over the concentration ranges of 2.5-50 and 1-30 μg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets.

Keywords

Spectrophotometric Analysis, Classical Least Square Method, Candesartan, Hydrochlorothiazide.

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S. J. Daharwal ¹, Veena Devi Thakur ¹, Shikha Shrivastava ¹, Bhanu Pratap Sahu ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN

Abstract

The present work deals with optimization of designed MCG , so that the best possible set of parameters affecting result can be selected to get the desired output. In this report nine batches of formulations (F1-F9) prepared and studied. Two variables were selected for the formulations in which first was concentration of elastomer and other was concentration of softener. The mathematical models developed for all the dependent variables using statistical analysis software Design experts 8.0.1.Percent Drug release of various formulation F2, F5, F8 andF9 was found to be 95.31, 98.74, 88.18 and 91.74. The highest Percent of Drug release among all is of F5.

Keywords

Optimization, Medicated Chewing Gum, Ambroxol HCl.

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S. J. Daharwal ¹, Veena Devi Thakur ¹, Shikha Shrivastava ¹, Bhanu Pratap Sahu ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN

Abstract

Chewing gums cannot be assayed unlike tablet by the conventional method that is by crushing the tablet and weighing an accurate amount of medicament and estimating its content. For estimation of the drug content and the study of drug release process from chewing gums a new apparatus (Erweka's DRT 6 Chewing apparatus) has been designed which mimics the natural chewing actions. The drug content was found to be in the range of 95.20 to 99.21% or 28.56 to 29.76 mg. highest drug content and the lowest drug content were found with formulation F5 and formulation F7 of Ambroxol hydrochloride respectively. The present study deals with in-vitro drug release of Medicated chewing gumFormulation F5 showed highest drug release of 98.74% and formulation F7 showed lowest drug release of 85.74% respectively at the end of 30 minutes.

Keywords

Erweka DRT 6 Chewing Apparatus, Medicated Chewing Gum, Ambroxol HCl.

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