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Gaikwad, Ravindra
- In-Silico Study of Phytoconstituents From Tribulus terrestris As Potential Anti-Psoriatic Agent
Authors
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 267 - 274Abstract
Introduction: Psoriasis (Ps) is a well-known chronic non-infectious, inflammatory skin disease affecting about 2–3% of the worldwide Population. Pathogenesis includes the environmental trigger factors with other factors like genetic factors, trauma, chemicals, bacterial infection etc. Currently there is no drug which can permanently cure the skin lesions as well as completely eradicate this dermatosis. The purpose of this research is to investigate the anti-psoriatic activity of phytoconstituents of Tribulus terrestris by predicting the ligand-receptor binding and by predicting the ADMET parameters using Lipinski's rule. Methodology: The process of research work starts with protein and ligand structure preparation. Further docking was done using PyRxAutodock Vina. Afterward, analysis and visualisation of the interaction between protein-ligands was done, and ADMET profiling was carried out according to lipinski's rules using Swiss ADME. Result: we selected four phytoconstituents of Tribulus terrestris. Molecular docking simulation showed all four compounds had better binding affinities. Based on the results of prediction of ADMET values using the Lipinski rule, compound that are thought to have good activity. Conclusion: Based on results these molecules have discovered that they may be able to produce anti-psoriatic activity and found that they have a lower toxicity, and ADME analysis determined the easily absorbability to the tissue site. Hence, these compounds can be analysed by further in vitro studies and can be a leader in the designing of the potential drug for the psoriasis management.
Keywords
ADME prediction, binding affinity, drug-likeness, in-silico analysis, molecular docking, TribulusterrestrisReferences
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- Graphene Quantum Dots: A Pharmaceutical Review
Authors
1 Department of Pharmaceutics, Ashokrao Mane Institute of Pharmaceutical Sciences and Research, Save Maharashtra, 416213, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013 Department of Pharmaceutical Chemistry, Y.D. Mane Institute of Pharmacy Kagal, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 4 (2022), Pagination: 341 - 348Abstract
Quantum dots (QDs) possess exclusive physicochemical and optical properties which are suitable for devices like, optoelectronic devices, light-emitting diodes, and photovoltaic cells. Compared to the selenium and tellurium/metasulfide- based QDs, graphene quantum dots (GQDs) are less toxic and have more biocompatibility, these properties make them ideal candidates for the application in various fields like, drug delivery agents, bio-imaging, therapeutics, and theranostics. Different types of methods for the synthesis of GQDs like top-down and bottom-up methods are systematically deliberated in this study. Different physicochemical, optical, and biological properties are included in this particular text. These properties include size- and chemical-composition-dependent fluorescence, therapeutics, cellular toxicity, disease diagnostics, and biocompatibility. At last, predictions and possible directions of GQDs in drug delivery and bioimaging systems are deliberated concerning challenges such as synthesis, biocompatibility, and cellular toxicity.
Keywords
Bioimaging, Graphene Quantum Dots, Nanostructured graphene, Optical properties, Photoluminescence, Quantum dotsReferences
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