Asian Journal of Pharmaceutical Research

B. A. Bhairav ¹, J. K. Bachhav ¹, R. B. Saudagar ²

Affiliations
1 Department of Quality Assurance Techniques, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213 Maharashtra, IN
2 Department of Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

Absorption process is develop in biological system to getting required organic and inorganic chemicals in to systemic circulation and maintain bioavailability. The bioavailability issue can be due to insufficient solubility or permeability. Most compounds face the solubility problems. Hence, with the advancement of chemical science, the need of development of pharmaceutical technologies is also increasing and it depend upon drug to drug. The drug exhibit very poor aqueous solubility the rate at which drug dissolve in gastro intestinal tract and exhibit rate limiting step. Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effect On the basis of solubility, drugs are classified into four classes of the BCS classification. Solubility challenges are faced in the Class II and Class IV of the BCS system. To improve solubility and bioavailability of poorly soluble drug we use various methods or techniques. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.

Keywords

Bioavailability, Novel Methods, Solubility, BCS Class.

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S. Waghmare Sneha ¹, V. Kadam Trupti ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In the late years, exploratory and innovative progressions have been made in the innovative work of novel medication conveyance frameworks by overcoming physiological inconveniences, for example, short gastric habitation times and capricious gastric purging times. A few methodologies are as of now used in the prolongation of the gastric habitation times, including floating medication conveyance frameworks, swelling and stretching frameworks, polymeric bioadhesive frameworks, adjusted shape frameworks, high-thickness frameworks and other deferred gastric exhausting gadgets. The administration of sickness through solution is entering another period in which developing number of novel medication conveyance frameworks are continuously utilized and are accessible for helpful utilization. Oral maintained discharge gastroretentive measurements structures offer numerous favorable circumstances for medications with assimilation from upper parts of gastrointestinal tract and for those acting mainly in the stomach, enhancing the bioavailability of the pharmaceutical. Floating Gastroretentive Drug Delivery Systems (FGRDDS) is one among the gastroretentive measurements structures used to accomplish delayed gastric living arrangement time. The reason for composing this audit on skimming medication conveyance frameworks (FGRDDS) was to arrange the late writing with unique concentrate on the important instrument of floatation to accomplish gastric maintenance. The late advancements of FGRDDS including the physiological and definition variables influencing gastric maintenance, methodologies to plan single-unit and numerous unit coasting frameworks, and their arrangement and detailing angles are secured in point of interest. This survey likewise compresses the in-vitro strategies, in vivo studies to assess the execution and application of floating frameworks, and applications of these frameworks.

Keywords

Floating Gastroretentive Drug Delivery System (FGRDDS), Single Unit, Multiple Units, Recent Trends, In Vitro-In Vivo Evaluation.

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S. Zope Janhavi ¹, L. Sonawane Pradnya ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Floating drug delivery systems are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. Floating drug delivery systems are the systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drug. The single unit dosage forms have the disadvantage of a release all or nothing during emptying process while the multiple unit particulate system pass through the GIT to avoid the vagaries of gastric emptying and thus release the drug more uniformly. The uniform distribution of these multiple unit dosage forms along the GIT could result in more reproducible drug absorption and reduced risk of local irritation. The purpose of designing multiple-unit dosage form is to develop a reliable formulation that has all the advantages of a single-unit form and also is devoid of any of the above mentioned disadvantages of single unit formulations. This review explains briefly about advantages, disadvantages, mechanism, types, factors, evaluation and application of these systems.

Keywords

Gastro-Retentive Floating Drug Delivery System, Advantages, Disadvantages, Mechanism, Evaluation.

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S. B. Gondkar ¹, Namrata D. Patil ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, KCT’S RGS College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Oral fast dissolving films is relatively a new dosage form in which thin film is prepared using hydrophilic polymers which rapidly dissolves on tongue or Buccal cavity. The films overcome the fear of chocking. An ideal film should have the properties like pleasant taste, high stability, ease of handling and administration, no water necessary for application. Fast dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing.

Keywords

Fast Dissolving Film, Film Forming Polymer, Solvent Casting Technique, Patented Technology.

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Gunjan L. Zope ¹, A. B. Darekar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

In recent years the novel technology of floating drug delivery system formulations are designed for the new drugs for oral targeted drug delivery. The drugs are delivered by conventional dosage forms are having very short residence time, but the drugs which are act in stomach are have more residence time. The floating drug delivery systems are of particular interest for drugs that are locally active and narrow absorption window in stomach. Systems which are retained in the stomach for a longer period of time and there by improve the bioavailability of drugs. In this review the various advantages are given which are very important for controlled drug delivery system. Floating drug delivery systems have a bulk density less than gastric fluids. When the system floats on gastric contents the drug is released slowly at the desire rate from system. The polymers are suitable for floating drug delivery systems are covered in this review.

Keywords

Floating Drug Delivery System, Mechanism and types of FDDS, Evaluation of FDDS.

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R. B. Saudagar ¹, Kanchan T. Mandlik ²

Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjenari, Nashik, Maharashtra, IN

Abstract

This review is focused essentially on the types and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio. These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility. Gold nanoparticles can be functionalized with protein, peptides and nucleic acid. So these have a great application not only in bio sensing drugs but also in drug, gene and protein delivery.

Keywords

Gold Nanoparticle, Nanotechnology, Advantages, Applications.

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R. S. Kalkotwar ¹, R. B. Saudagar ²

Affiliations
1 Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN

Abstract

A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, ¹H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.

Keywords

QSAR, Antibacterial, Antifungal, Anti-Inflammatory Activity.

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