Asian Journal of Pharmaceutical Research

S. Sathish Kumar ¹, G. Melchias ¹, P. Ravikumar ², R. Chandrasekar ³, P. Kumaravel ⁴

Affiliations
1 Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, IN
2 Govt. Arts College (Autonomous), Coimbatore, Tamil Nadu, IN
3 Institute of Forest Genetics and Tree Breeding, Coimbatore, Tamil Nadu, IN
4 Department of Biotechnology, Vysya College, Salem, Tamil Nadu, IN

Abstract

Development of reliable green synthesis of silver nanoparticles by various plants and microorganisms has been reported in many research aspects. However, the probable of plants as natural materials for the synthesis of nanoparticles and their compatibility to biological systems is yet to be fully explored. In this study, we report a simple green method for the synthesis of silver nanoparticles using Euphorbia hirta (E. hirta) leaves extract as a reducing and stabilizing agent. After exposing the silver ions to E. hirta leaves extract, rapid reduction of silver ions is observed leading to the formation of silver nanoparticles in solution. The synthesized nanoparticles were characterized by using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), Field emission Scanning Electron Microscopy (FESEM) and Particle size analysis. The synthesized silver nanoparticles show maximum zone of inhibition against Bacillus subtilis, Vibrio cholera and Salmonella typhi.

Keywords

Silver Nanoparticles, E. hirta, Antimicrobial Activity.

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T. Jeyanthi ¹, P. Subramanian ², P. Kumaravel ³

Affiliations
1 Department of Biochemistry, Achariya Arts and Science College, Villianur, Pudhucherry-605110, IN
2 Department of Biochemistry and Biotechnology, Annamali University, Chidambaram-608002, Tamilnadu, IN
3 Department of Biotechnology, Vysya College, Salem-636103, Tamilnadu, IN

Abstract

Antibiotics play a major role in clinical medicine in eradicating pathogens. Unfortunately, excessive/inappropriate use of antibiotics has contributed to the spread of important clinical and public health problems of antibiotics resistance. The present study aimed to examine a comparative analysis of the antibacterial efficacy of ethanol and methanol ischolar_main extracts of W. somnifera with commercial antibiotics against the bacterial strains. The ethanol and methanol ischolar_main extracts of W. somnifera found to show equalent/potent antibacterial activity against the bacterial strains as compared to antibiotic discs. Methanol ischolar_main extract of W. somnifera showed an effective antibacterial activity might be due to presence of numerous bioactive compounds. Thus, there is a tremendous need for future research to provide better evidence, to address the isolation and characterization of these bioactive components of methanol ischolar_main extract of W. somnifera responsible for the antibacterial activity, offer an ecologically and economically safe drug compared to commercial antibiotics.

Keywords

Antibacterial Activity, W. somnifera, Antibiotics, Gentamicin, Tetracycline.

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