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Mahurkar, Nitin
- Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin Induced Peptic Ulcers
Authors
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga – 585 105, Karnataka, IN
2 Department of Pharmacology, Sai Pranavi College of Pharmacy, Keesara, Hyderabad – 501 504, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 1 (2015), Pagination: 10-14Abstract
The aim of the present study is to assess the synergistic effect of melatonin and esomeprazole combination in the treatment of peptic ulcers using Pylorus ligation, Ethanol and Aspirin ulcer inducing models. Wistar albino rats of either sex weighing between 180-200 gms were used in the study. For each ulcer model, the animals were randomly divided into 04 groups of 06 animals in each. Following acclimatization, the animals were subjected to administration of drugs and combination for 07 consecutive days. On the 7th day, after the administration of the drugs, the animals were fasted for 48h. At the end of 48h, the animals were subjected to ulcer induction using pylorus ligation, ethanol (1ml/200gm; p.o.) and aspirin (20mg/kg; p.o.) models. Various biochemical parameters were assessed - in pylorus ligation model, pH, volume of gastric juice (ml), free and total acidity (mEq/L) and ulcer index were assessed and in aspirin and ethanol induced ulcer models, ulcer index and percentage protection were evaluated. The results were interpreted using one way ANOVA followed by Dunnett's test. It was observed that the combination was effective synergistically in treating peptic ulcers, as it significantly enhanced the antiulcer effect upon comparison with the other treatment groups. From the results obtained, it was concluded that the combination is synergistic in nature.Keywords
Antioxidant, Melatonin, Proton Pump Inhibitor, Esomeprazole.
- Antiulcer Activity of Commicarpus chinensis in Ethanol and Aspirin Induced Ulcers
Authors
1 Department of Pharmacology, HKES College of Pharmacy, Gulbarga–585 105, Karnataka, IN
2 Department of Pharmacology, MAK College of Pharmacy, Moinabad–501 504, Andhra Pradesh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 4, No 3 (2014), Pagination: 119-122Abstract
Aim: To assess the antiulcer effect of aqueous leaf extract of Commicarpus chinensis in ethanol and aspirin induced ulcerations.
Material and Method: Wistar albino rats of either sex weighing between 180-220g were used for the study. The plants were collected from Gulbarga University campus, Gulbarga, Karnataka and shade dried, subjected to soxhlet extraction using water as solvent to obtain aqueous extract. The extract was evaluated for its antiulcer activity by using ethanol, aspirin induced ulcer models. For each model, the animals were divided into 3 groups of 6 animals in each. The animals were fasted for 48h and subjected to ulcer induction for evaluating the antiulcer effect of C. chinensis. Prior approval of the IAEC was obtained for conducting antiulcer experiment.
Results: The results were interpreted using one way ANOVA, followed by Dunnett's test. The aqueous leaf extract showed significant antiulcer activity on comparison with standard drug rabeprazole. The aqueous extract significantly reduced the ulcer index and enhanced the percentage protection in a dose dependent manner.
Conclusion: The antiulcer effect of C. chinensis may be due to antioxidant property due the presence of tannins, flavonoids, saponins. C. chinensis is an effective antiulcer agent.