Asian Journal of Pharmaceutical Research

D. Sunitha ¹, K. Hemalatha ², M. Sudhakar ¹

Affiliations
1 Malla Reddy College of Pharmacy (Osmania University), Maisammaguda, Hyderabad, Telangana, IN
2 Acharya B. M. Reddy College of Pharmacy, Bangalore, Karnataka, IN

Abstract

Drugs are made to save lives and not cause deaths. Every drug has some side effect if the dose of the drug is correct, then it can be avoided. Some drugs side/ adverse effects can be reduced by another drug. Hence, doctor prescribed medication is safer then self medication. Banned drugs have more adverse/ side effects. Doctors should stop prescribing banned drugs and due to less demand manufacturer will not produce such drugs. As well as the government should make strict laws against the peoples involved in manufacturing and selling of banned drugs. Government should be ordered to dump these cheap drugs in proper manner. And also, India's pharmacovigilance effort has to be scaled up rapidly. People should say stop selling banned drugs.

Keywords

Banned Drugs, Market, Committee, Chemicals, Illegal Drugs.

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Dasari Nirmala ¹, Swapna Nandhini ¹, M. Sudhakar ¹

Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally and Secunderabad -500100 Affiliated to Osmania University, IN

Abstract

Present research was aimed with the objective of formulation of Zolpidem fast dissolving oral films, for rapid dissolution of drug and absorption, which may produce the rapid on set off action. The fast dissolving oral films were prepared by solvent casting method using various polymers like HPMC E5, HPMC E15, HPMC K15, microcrystalline cellulose and poly vinyl alcohol. Glycerol used as plasticizer. Prepared films were evaluated for various physicochemical parameters like film thickness, tensile strength, folding endurance, content uniformity, estimation of moisture content, disintegration studies and dissolution studies. As polymer concentration increases thickness increases. Thickness directly proportion to tensile strength so as thickness increases tensile strength also increases. Folding endurance increases as polymer concentration increases. The moisture uptake studies revealed that, the film take up very little moisture (1-2%) in high humid environment, hence this may favors the stability as well as compatability. In vitro drug release studies reveals that among all formulations F7 formulation highest amount of drug release compared to other formulations, hence F7 formulation was taken as optimized formulation for further studies. Short term stability studies were conducted for optimized formulation up to 3 months at 40±2c 75% R.H. after stability studies films were transparent all physical parameters were favorable and drug release was satisfactory.

Keywords

Fast Dissolving Films, Zolpidem, Solvent Casting Method, HPMC E5, E15 and K15, Oral Thin Films.

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V. Uma Rani ¹, M. Sudhakar ¹, A. Ramesh ²

Affiliations
1 Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, Affiliated to Osmania University, Telangana, IN
2 Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Telangana, IN

Abstract

Pueraria tuberose Linn. is an inexpensive and efficient source to provide all the required nutrients and medicinal benefits for a healthy and rejuvenating body. The present investigation has been undertaken to evaluate the role of Pueraria tuberosa Linn. in modifying the sodium arsenate induced biochemical alterations in albino rats. Administration of sodium arsenate in rats induces oxidative stress, which leads to the generation of free radicals in the body. These free radicals interact with tissue leading to tissue damage i.e, kidney damage. Animals were divided into 6 groups, Group I (control group) rats were treated with normal saline (1mg/kg), Group II ( Positive Control) rats were treated with sodium arsenate (1mg/kg).Group III rats were treated with sodium arsenate (1mg/kg) and Vitamin E (100 mg/kg).Group IV rats were treated with sodium arsenate (1mg/kg) and Pueraria tuberosa linn. extract (50 mg/kg), Group V rats were treated with sodium arsenate (1mg/kg) and Pueraria tuberosa linn. extract (100 mg/kg) , Group VI rats were treated with sodium arsenate (1mg/kg) and hydroalcoholic extract of Pueraria tuberose linn (200mg/kg). After 21 days treatment, blood samples were collected and analyzed for the serum parameters viz BUN test, serum calcium test, serum iron test, Acid phosphatase test, Creatinine test. Antioxidant parameters like Malondialdehyde, catalase, Reduced glutathione and glutathione reductase were estimated. The kidney is removed and sectioned for histopathological examination. The hydroalcoholic extract of Pueraria tuberosa linn (tuber) inhibits the oxidative stress hypothesis mechanism. It was concluded that the extract of Pueraria tuberose linn (tuber) exerts nephroprotective activity could be attributed by presence of natural antioxidants, free radical scavenging.

Keywords

Sodium Arsenate, Nephrotoxicity, Blood Toxicity, Oxidative Stress, Kidney Ctamases.

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