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Goyal, Kamya
- A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone
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Authors
Dheeraj Singh
1,
Vishal Kaundal
1,
Neha Aggarwal
1,
Shammy Jindal
2,
Amar Deep Ankalgi
1,
Kamya Goyal
1
Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 37 - 44Abstract
Chalcones and their derivatives have been an area of great interest in recent years. Numbers of research publications have been published and chalcones continue to show promising effect for new drug investigations. Chalcone is an advantageous species with medicinal importance as it is consisting of highly reactive ketoethylenic system –CO–CH=CH– which belongs to flavonoids. Chalcones (1, 3-Diphenyl-2-propen-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. However, synthesis in laboratory of broad range of chalcones has also been reported. In chalcone and its derivatives, a highly reactive α, β-unsaturated carbonyl system is the major reason for their pharmacological potencies. Chalcones and their derivatives are known to show a wide range of pharmacological potencies such as anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antigout, antihistaminic, antiviral, antimycobacterial etc. Chalcones can be prepared by Claisen– Schmidt’s condensation, Aldol condensation, Heck’s reaction, Suzuki’s reaction, Ultrasound method of synthesis, Solvent free synthesis of chalcones, One pot synthesis, Sonogashira Isomerization coupling reaction etc. The purpose of the present review is to focus on the various methods of preparation of chalcones and derivatives and their anti-inflammatory and antioxidant potencies.
Keywords
Chalcone, Claisen–Schmidt condensation, Aldol condensation, anti-inflammatory, antioxidant
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Authors
Affiliations
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 76 - 83Abstract
In the past 15 years, breakthroughs in the understanding towards the pathogenesis of psoriasis have been translated into highly and targeted effective therapies which provides fundamental insights into the pathogenesis of chronic inflammatory diseases. In this article we understand the mechanisms involved in the initiation and development of psoriasis, as well as the therapeutic options that arises from the dissection of the inflammatory psoriatic pathways. The whole discussion begins by addressing the inflammatory pathways and key cell types which initiating and perpetuating the psoriatic inflammation. Also, we discuss the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. So, we the purpose of our study is to understand psoriasis comprehensively, and this review is well-established to explain the therapies, and other novel targeted drugs that are mostly used in the effective treatment of psoriasis.
Keywords
Psoriasis, Types, Pathogenesis, Epidemiology, PharmacotherapyReferences
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