Asian Journal of Pharmaceutical Research

Hisham A. Abbas ¹

Affiliations
1 Department of Microbiology and Immunology, Zagazig University, Zagazig, EG

Abstract

Diabetic foot infection is a serious complication of diabetes that can lead to amputation of lower extremities. Proteus mirabilis is common in diabetic foot infections. These infections are problematic in treatment due to high resistance to antibiotics and biofilm formation. This study investigated the antimicrobial, anti-swarming and antibiofilm activities of local Egyptian clover honey against a clinical Proteus mirabilis isolate from diabetic foot ulcer. Honey is one of the oldest remedies for wound infections. Honey at a concentration of 40% was bactericidal to the planktonic cells of Proteus mirabilis. Swarming and biofilm formation are correlated. At 1/2 MIC of honey, it completely blocked swarming of Proteus mirabilis on 1.5% Luria-Bertani (LB) agar and inhibited biofilm formation by a percentage of 85.86±3.41. This study suggests the use of clover honey as an alternative therapy for treatment of diabetic foot infections caused by Proteus mirabilis due to combined antibacterial, anti-swarming and antibiofilm activities.

Keywords

Anti-Swarming, Antibiofilm, Clover Honey, Proteus mirabilis, Diabetic Foot Infection.

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Hisham A. Abbas ¹, Fathy M. Serry ¹, Eman M. EL-Masry ¹

Affiliations
1 Department of Microbiology and Immunology, Zagazig University, Zagazig, EG

Abstract

Biofilm-associated infections are persistent and difficult to treat due to the multifactorial antimicrobial resistance. Sugar alcohols have a significant inhibitory effect on dental biofilms. They can reduce the amount of dental plaque and the extracellular polysaccharide (glucans) and intracellular matrix production. The interference with the production of glucans could decrease the extracellular matrix component of mixed oral biofilms.

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