Asian Journal of Pharmaceutical Research

Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

The aerial part of Leucas zeylanica (L.) Benn (Fam. Lamiaceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Leucas zeylanica which possess characters like deep green colour, characteristic odor and mucilaginous and slightly bitter taste. The fluorescence analysis under visible light and under UV light by treatment with different chemical reagents showed different colour changes. The presence of alkaloids, steroids, tannins, flavonoids and glycosides were confirmed during preliminary phytochemical screening.

Keywords

Organoleptic, Fluorescence, Phytochemical, Supernatant.

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Dibyajyoti Saha ¹, Swati Paul ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

The aerial part of Vernonia patula (family: Asteraceae) was studied to fix the parameters for pharmacognostical standards. The results of organoleptic study offer a scientific basis for the use of Vernonia patula which possess characters like green colour, characteristic odour, mucilaginous and slightly bitter taste. The fluorescence analysis under visible UV light and under UV light by treatment with different chemical reagents showed different colour changes. These created an interest to test the possible phytochemical activity of the plant. In the screening process of Vernonia patula indicate the presence of Reducing sugars, Steroids, Alkaloids, Glycosides, Tannins, and Gums. The Pharmacognostic study was performed by using standard procedure. Further, detailed studies are needed to know whether in-vivo administration of the extracts is beneficial for patients.

Keywords

Organoleptic, Fluorescence, Pharmacognostic Study.

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Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

Bacterial infections are one of the prominent causes of health problems, physical disabilities and mortalities around the world. Symptoms and complications associated with bacterial infections such as fever, chills, headache, nausea, vomiting and organ failures affect patient's life severely. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost effective way of treating bacterial infections. We report in this work for the first time, the potent antibacterial activity of different leaf extracts of Barleria prionotis L. The objectives of this study were to examine the antibacterial effect using different extract [petroleum ether (40°-60°), chloroform, ethanol (70%)] and column fraction of Barleria prionitis Linn (Acanthaceae) leaf and to determine the minimum inhibitory concentration (MIC) of the different Barleria prionitis Linn (Acanthaceae) leaf extract and column fraction. S. typhi (Ty 2-59) [Chloroform extract, Column fraction]; V. cholerae (DN-6) [Column fraction]; V. cholerae (793) [Chloroform extract]; V. cholerae (813) [Chloroform extract, Column fraction]; M. luteus (ATCC-9341) [Chloroform extract, Column fraction]; L. sporogenus [Chloroform extract] and Citrobacter [Chloroform extract, Column fraction] were inhibited at 5mg/ml level. B. subtils (PI-6633) [Pet. ether extract] inhibited at 3.33mg/ml level. B. cereus (PI-11778) [Column fraction] and Providencia [Chloroform extract, Column fraction] were inhibited at 50mg/ml level.

Keywords

Barleria prionitis, Antibacterial Activity, Minimum Inhibitory Concentration (MIC).

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Swati Paul ¹, Dibyajyoti Saha ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

Evaluation of antimotility activity was done in intestine of mice treated with methanolic extract of Alpinia conchigera Griff (MEAC). Charcoal was used as a promotility agent. The antimotility activity with the mean defecation period 297.4 and 371.2 min at the dose of 250 and 500mg/kg body weight.

Keywords

Alpinia conchigera Griff, Gastrointestinal Motility, Chacoal.

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Dibyajyoti Saha ¹, Swati Paul ¹

Affiliations
1 Department of Pharmacy, BGC Trust University, Chittagong, BD

Abstract

Investigation with crude methanolic extract of Alpinia conchigera Griff was carried out to evaluate its possible cytotoxic activity. Pharmacological history of this plant promoted us to check the possible cytotoxic activity. By using the brine shrimp lethality bioassay method, the LC50 and LC90 value of Alpinia conchigera Griff were assayed. In this study, DMSO was used as solvent. The extract evidence cytotoxic activity against brine shrimp nauplii and calculated LC₅₀ and LC₉₀ value was 6.1μg/ml and 12.2 μg/ml respectively.

Keywords

Alpinia conchigera Griff, Cytotoxicity, LC₅₀, Brine Shrimp Lethality Bioassay, LC₉₀.

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Dibyajyoti Saha ¹, Ankit Tamrakar ¹, Mayukh Jana ², Supradip Mandal ²

Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur-495004, C.G., IN
2 Bharat Technology, Banitabla, Uluberia, Howrah-711316, IN

Abstract

Protection against sun-induced damage leading to photo carcinogenesis in skin is a highly desirable goal. Epidemiological and experimental studies provide evidence that some naturally occurring chemical agents in the human diet can diminish cancer risk. Extensive documentation has validated the role of UV irradiation as a tumor initiator and promoter, inducing both squamous and basal cell carcinomas. Development of skin cancer has been frequently observed in patients with XP. This disease is characterized by deleterious mutations in the genes involved in the DNA damage repair system, with a marked reduction in the ability of its cells to repair potentially carcinogenic mutations mainly those caused by UV, thus making these patients highly photosensitive and predisposed to skin cancer. The article highlights important factors, types of skin cancer with its mechanisms and prevention strategy.

Keywords

Skin Cancer, Carcinoma, Melanoma, Papilloma Virus, Tumor.

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