Asian Journal of Pharmaceutical Research

Lalita Balasaheb Patil ¹, Swapnil S. Patil ², Manoj M. Nitalikar ², Chandrakant S. Magdum ², Shrinivas K. Mohite ²

Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Walwa Dist- Sangli ( Maharashtra), IN
2 Rajarambapu College of Pharmacy, Kasegaon, IN

Abstract

Nanorobotics is emerging field of a nanotechnology having nanoscale dimensions and is predictable to work at an atomic, molecular and cellular level. Nanorobot skeleton is made up of carbon and its toolkit contains components like medicine cavity containing medicine, microcamera, payload, capacitor and swimming tail. As nanorobots have special sensors i.e. physical or chemical which detect the target molecules in the human body can be used for the diagnosis and treatment of various vital diseases i.e. cancer, diabetes, atherosclerosis, hemophilia, kidney stones, etc. Nanorobots till date are under the line of investigation, but some primary molecular models of these medically programmable machines have been tested. This review on nanorobots presents the various aspects allied i.e. introduction, history, ideal characteristics, Approaches in Nanorobotics ,basis for the development, tool kit recognition and retrieval from the body, application considering diagnosis and treatment.

Keywords

Nanorobots, Atherosclerosis, Nanosensors, Nanoscale.

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Sandeep B. Patil ¹, Nilofar S. Naikwade ¹, Chandrakant S. Magdum ², Vikas B. Awale ³

Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
3 Department of Botany, Dr. Patangrao Kadam Mahavidyalya, Sangli, Maharashtra, IN

Abstract

Region of Southern Maharashtra has large floristic world which will depend on proper utilization of plant reserve. The paper reports the age old empirical ethno-medicinal knowledge of twenty six plants species belonging to nineteen families from rural populace of Sangli district, Maharashtra.

Keywords

Ethnobotany, Medicinal Plants, Vaidu, Maharashtra.

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Sandeep B. Patil ¹, Nilofar S. Naikwade ¹, Chandrakant S. Magdum ², Vikas B. Awale ³

Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli, IN
2 Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
3 Department of Botany, Dr. Patangrao Kadam Mahavidyalya, Sangli, Maharashtra, IN

Abstract

Region of southern Maharashtra has large floristic world which will depend on proper utilization of plant reserve. The paper reports the age old empirical ethno-medicinal knowledge of thirty plants species belonging to twenty families from rural populace of Sangli district, Maharashtra.

Keywords

Ethnobotany, Medicinal Plants, Vaidu, Maharashtra.

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Rutuja S. Shah ¹, Rutuja R. Shah ¹, Manoj M. Nitalikar ¹, Chandrakant S. Magdum ¹

Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon-415404, Tal-Walwa, Dist-Sangli, IN

Abstract

The main objective of work was to develop pharmaceutically elegant and stable enteric coated tablet formulation for highly unstable drug in acidic environment using pH dependent polymer. Development of Enteric coated tablets were done for Controlled Release of drug. Coating was done by using methacrylic acid copolymer (Eudragit L 100). Characterization of Drug and Excipients was carried out including compatibility studies of drug and excipients. Solid dispersion of glimepiride was formulated using carrier PEG20000 was prepared by the Fusion method. Evaluation of Solid was carried out using suitable parameters like solubility, percentage yield, drug content, in-vitro drug release, FTIR and SEM. Further granules were formulated from the optimized batch of formulated SDs. Pre-compression studies of granules were carried out like Tapped density, Bulk density, Angle of repose, etc. of Granules. Four different batches were formulated of tablets. The tablets were evaluated for various parameters like weight variation, hardness, friability, thickness, disintegration and in-vitro drug release. For Dissolution studies, 7.4 phosphate buffer media was used. The optimized batch of tablets was further subjected to enteric coating using pan coating. Eudragit L100 was used as coating polymer and isopropyl alcohol, acetone and triethyl citrate were used as vehicle in solution. Eosine was used as colorant. The coating solution was prepared in three different concentrations viz., 1%, 2%, and 3%. The coating solution was sprayed on tablets using spray gun and after drying the tablets were evaluated for different parameters like in-vitro drug release and disintegration, Hardness, thickness, friability, drug content and weight variation. Here, as the tablet was enteric coated, 2 dissolution medias were used 7.4 phosphate buffer and 0.1 N HCl. Further Stability studies were carried out of optimized batch. Results obtained after the stability studies confirmed that prepared enteric coated tablets were stable at applied conditions and were complied with the initial results.

Keywords

Solid Dispersion, Tablets, Enteric Coating, Eudragit L100, Stability Studies.

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Rutuja S. Shah ¹, Rutuja R. Shah ¹, Manoj M. Nitalikar ¹, Chandrakant S. Magdum ¹

Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon-415404, Tal-Walwa, Dist-Sangli, IN

Abstract

A major challenge in the drug development and delivery process is improving aqueous solubility and rate of dissolution of drugs, which ultimately improves absorption of the drug. Bicalutamide is most useful drug in prostate cancer treatment it is a non-steroidal antiandrogen. It comes under class of poorly water-soluble drug. Poor water-solubility of drugs leads to slow drug absorption, and low bioavailability, for which its solubility is to be enhanced to improve the oral bioavailability of the. One of the possible way to overcome this outcome is to use formulate solid dispersion by using spray drying technique. Spray-drying is a unit operation by which a liquid product is atomized in a hot gas current to instantaneously obtain a powder. The purpose of this research was to improve the solubility profile of Bicalutamide by spray drying technique using Methanol and Polyvinyl pyrolidone-K30. Prepared solid dispersions were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied.

Keywords

Solubility, Bicalutamide, Prostate Cancer, PVP-K30, Solid Dispersion.

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