Asian Journal of Pharmaceutical Research

Smriti Khatri ¹, Babita Sarangi ¹

Affiliations
1 Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, IN

Abstract

The gene medicine technology is a viable source for developing therapeutics for a wide range of disorders in human beings. It includes potent therapeutics like plasmids containing transgenes, oligonucleotides, aptamers, ribozymes, DNAzymes, and small interfering RNAs which are powerful mechanisms for gene silencing to address desired location of drug in the body. Gene therapy has been utilized for the treatment of several diseases, specially cancer which can be achieved by the introduction of a nucleic acids such as antisense oligonucleotides or smallinterfering RNA to inhibit transcription or translation of a cancer causing oncogene. The present review discusses the recent developments in nucleic acid based targeted drug delivery.

Keywords

Nucleic Acids, DNA Building Blocks, Oligoneucleotides.

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Smriti Khatri ¹, Babita Sarangi ¹

Affiliations
1 Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, IN

Abstract

Conventional drug delivery system gives as well as maintain the steady state drug concentration in blood by increasing the dosing frequency so many times. A rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamic profiles is to retain the drug reservoir above its absorption area, to release the drug in a controlled manner. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile is to control the gastric residence time in GIT. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. This review explains briefly about Gastroretentive approaches, evaluation various floating drug delivery systems and application of these systems.

Keywords

Gastrointestinal Tract, Floating Drug Delivery, Evaluation.

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