Asian Journal of Pharmaceutical Research

S. Swathi ¹, B. Swathi ², Kasireddy Swapna ¹, G. Venkateshwarlu ¹, B. Swathi ², N. Sharada ¹, P. Laxmi ¹

Affiliations
1 Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda, Telangana, IN
2 Department of Pharmacy, Palamuru University, Mahabubnagar, Telangana, IN

Abstract

Now a day's peoples are completely habituated for cool life or without hard work so this reason causes many diseases. Recently most of the software employees yield for spondilysis, gastritis, heart stroke, brain stroke and paralysis etc. especially throughout world youth suffering with stress condition and money earning pressure and restless work, mechanical life also causes various diseases. Recently in Nalgonda one survey held on brain stroke and kidney failure, paralysis. In that survey as a pharmacist and other doctors are conducted for every 100 persons participated in that 7 members are heart stroke, 5 persons are kidney failure, 3 are paralyzed persons are there. This survey carried at Government hospital, Gollguda, Nalgonda, Telangana. why this ailments are raising means lack of exercise, fast food eating, environmental pollution, restless life, insomnia, companies task pressure on employ along with lot of reasons are there.

Keywords

Heart Stroke, Kidney Failure, Paralysis, Disease Survey.

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N. M. Vageesh ¹, Ramya Sri Sura ², K. Gulijar Begum ², B. Swathi ²

Affiliations
1 St. Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur, Kurnool (Dist), Andhra Pradesh, IN
2 Department of Pharmaceutics, Osmania University, Hyderabad, IN

Abstract

In the present research work gastro retentive floating matrix formulation of Lafutidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers Xanthan gum, guar gum and Sodium Alginate as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations Only Xanthan gum, Sodium Alginate highest concentrations (60 mg) retards the drug release upto 12 hours and the drug release 96. 25%, 95. 81% respectively. In this Xanthan gum releases the more drug release when compared to Sodium alginate. So F3 Formulation considered as optimized formulation. Optimised formulation F3 was kept for release kinetic studies. From the above graphs, it was evident that the formulation F3 was followed the Peppas release mechanism.

Keywords

Lafutidine, Xanthan Gum, Guar Gum and Sodium Alginate, Floating Tablets.

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